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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

PSP rejuvenating the South African professoriate
2016-10-25

Description: Dr Olihile Sebolai  Tags: Dr Olihile Sebolai

Dr Olihile Sebolai (Microbiology) is
one of two Fulbright scholars the
UFS Prestige Scholars’ Programme
has produced. He was a Fulbright
scholar at the University of Missouri
(Kansas City) and before that
conducted work at the University
of Birmingham in the UK.
Photo: Anja Aucamp

Twenty years. That is the difference between the average age of a UFS Prestige Scholar (35) and the average age of a South African academic (55). Since its inception in 2011, the UFS’s Prestige Scholars’ Programme (PSP) has pro-actively addressed the ageing profile of academia and the need to transform the social composition of the South African academy. In doing so it has generated more than R67 million in research funding, including R10 million in student and post-doctoral funding.

The programme seeks to identify, cultivate and promote outstanding scholarship among “young” members of the UFS academic staff – those who have acquired a doctorate within the last five years. It provides support (funding applications, report writing, etc.) and helps with international placements in order to accelerate the establishment of an international footprint in expectation of the participants’ entry into the professoriate.

The programme mentors scholars from five faculties at the UFS. PSP scholars have conducted research and established collaborations in North America, Europe and Japan at institutions such as Harvard, UCLA, Cornell University, University of Michigan, University of Missouri, University of British Columbia, Oxford University, Cambridge University, University of Manchester, University of Birmingham, Basel University, University of Bologna, Leiden University, Uppsala University, Okinawa Institute of Science & Technology and Obihiro University of Agriculture and Veterinary Medicine.

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