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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Valour inspires book on community protests
2016-10-18

Description: Dr Matebesi book cover Tags: Dr Matebesi book cover

The cover of Dr Sethulego Matebesi’s
book, Civil strife against local governance:
Dynamics of community protests in
contemporary South Africa, that will be
released on 1 November 2016.
Photo: Supplied

Two significant political events: the murder of an unarmed protester, and school children forced out of school sparked the idea to write a book on community protests.
The book, Civil strife against local governance: Dynamics of community protests in contemporary South Africa, by Dr Sethulego Matebesi, gives an academic account of service delivery protests in South Africa.

Research address protests in different communities
“The focus of my book is on community protests directed against municipalities in both predominantly black and white communities,” Dr Matebesi, senior lecturer in the Department of Sociology at the University of the Free State, said. The funding for the book was received from the National Research Foundation and the Erasmus Mundus EU-Saturn Scholarship.

Informs literature on service delivery protests
The struggle against municipalities reaches across geographic and demographic boundaries, but the violent turn of protests in black communities in contrast to white communities has become somewhat of a hegemonic account by scholars. “The book connects the critical issue of community protests with the equally precarious issue of political trust in local government,” Dr Matebesi said. Case studies in the book are indicative of significant shifts in community protest – thus making it timely. Dr Matebesi said: “The book informs the growing literature on community protests and also fills an empirical void by including protesters in residents’ associations.”

“The book is a personal milestone and
the single greatest return on the
sacrifices made over the past 4 years.”





Personal milestone worth the sacrifice
Research was conducted between 2012 and 2015, whereby two case study sites were selected in four provinces to account the different tactics used. “The book is a personal milestone and the single greatest return on the sacrifices made over the past four years,” Dr Matebesi said.

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