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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Groundwater management vital for groundwater sustainability
2016-11-09

Description: Dr Yolanda Kotzé Tags: Dr Yolanda Kotzé

Dr Yolanda Kotzé, Affiliated Researcher in the
UFS Institute for Groundwater Studies, is passionate
about the management of groundwater.
Photo: Rulanzen Martin

An interest in groundwater resource management ignited the spark for a PhD research thesis by Dr Yolanda Kotzé, Affiliated Researcher in the Institute for Groundwater Studies (IGS) at the University of the Free State (UFS).

Her PhD research thesis titled, A Framework for Groundwater Use Authorisations as Part of Groundwater Governance in Water Scarce Areas within South Africa, was the result of her interest in groundwater resource management. Dr Kotzé identified the agricultural sector as one of the major water users, and a decision was made to conduct research within this sector.  

Research funded by Institute for Groundwater Studies
Groundwater is water found underground in cracks and spaces in soil, sand, and rocks. It is stored in, and moves slowly through geological formations of soil, sand, and rocks (aquifers). The National Department of Water and Sanitation was indirectly the client for this research. The research project was funded by the IGS. Given the current drought, effective groundwater resource management can be achieved within all sectors through sustainable abstraction and use without over-abstraction.

“Groundwater can be effectively managed
in the agricultural sector by sustainable use,
monitoring the quantity of groundwater use,
and measuring groundwater levels,”
said Dr Kotzé.

Research addresses improvement of groundwater management
Her promotor, mentor, teacher, and friend, the late Prof Gerrit van Tonder, introduced her to the field of Geohydrology, and especially to groundwater resource management. “With my research, I made a significant contribution to the improvement of groundwater governance and groundwater resource management, as well as to the handling of groundwater use authorisations for irrigation purposes in South Africa,” said Dr Kotzé. With this significant contribution, she attempts to address the phenomenon of poor groundwater allocation and groundwater resource management by means of a framework. The development of this framework has shown the value of action research in an attempt to find a solution to a problem. “Groundwater can be effectively managed in the agricultural sector by sustainable use, monitoring the quantity of groundwater use, and measuring groundwater levels,” said Dr Kotzé.

The methodology of the research consisted primarily of action research, which has a five-phase cyclical process. The research was Dr Kotzé’s application for a PhD in Geohydrology at the UFS in 2012. The research was completed in 2015.

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