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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Odeion String Quartet performs in Tanzania and Austria
2016-11-18

Description: Odeion String Quartet performs in Tanzania and Austria Tags: Odeion String Quartet performs in Tanzania and Austria

The Odeion String Quartet will build
international relationships when
it visits Tanzania and Austria.
Photo: Supplied

To be an ambassador for the University of the Free State (UFS) is a goal of the Odeion String Quartet (OSQ) and that is exactly what it will do through international visits to Tanzania and Austria. The OSQ, the only residential university quartet in South Africa, will play concerts abroad, share knowledge and build relationships.

It visits Dar es Salaam, Tanzania, from 17 to 20 November 2016 and Austria from 29 November to 4 December 2016. The quartet, which constitutes string lecturers at the Odeion School of Music, consists of Samson Diamond, Sharon de Kock, Jeanne-Louise Moolman and Prof Anmari van der Westhuizen Joubert.

A humbling experience
The OSQ was invited by Hekima Raymond, founder and conductor of the Dar Choral Society, to Tanzania to assist the symphony orchestra. Raymond is a self-taught pianist and conductor and was nominated for a BBC Outlook Inspirations award in 2016.

The quartet will lead the string sections of the orchestra, consisting of members from Uganda, Kenya and Tanzania, performing Beethoven’s fifth symphony and Verdi’s Requiem.

According to Diamond it is a humbling experience, an opportunity to extend their services and help establish the Dar Choral Society. “You are part of something really special, because the circumstances are remote if you compare it to what we have here.”

He means it is important to have a real African footprint and being involved there can later serve as a platform for UFS recruitment.

“You are part of something really special,
because the circumstances are remote if
you compare it to what we have here.”

South African and Austrian collaboration
According to Prof Van der Westhuizen Joubert it is an honour to play in Austria, as Europe is a centre for classical music. The OSQ will play concerts at the Alte Schmiede, Vienna, and the University of Salzburg.

The concert on 4 December 2016 at the University of Salzburg’s Mozarteum is a highlight because the UFS will have the opportunity to build relationships with the famous music school.

Prof Van der Westhuizen Joubert said it would be a South African/Austrian collaboration. “We will bring them South African works (Mokale Koapeng, AJ Feder, Arnold van Wyk and Peter-Louis van Dijk) and will be playing Austrian contemporary string quartets.”

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