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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS Business School positioned as key partner in the fight against fraud

2016-11-21

A collaborative effort to curb the scourge of fraud in public and private companies has been identified as the most effective method at the launch of International Fraud Awareness week, 13-19 November. The programme kicked off with a media briefing held in Bloemfontein, under the theme: “Curb Fraud and Accelerate Economic Transformation”. At this occasion, the Free State Provincial Treasury and key partner institutions which are: UFS Business School, Standard Bank, Association of Certified Fraud Examiners (ACFE), and PricewaterhouseCoopers, made a pronouncement on their efforts to stop fraud in public and private institutions.

Strategic partnerships empower companies
The UFS Business School, in collaboration with Strategic Investigations and Seminars, formed a collaborative effort to present the Advanced Certificate in Fraud Examination, thus empowering individual companies to have within their ranks, certified fraud examiners. The programme is a registered SAQA, NQF level 7 course comprising four modules; Law, Investigation, Fraud Prevention, Detection and Ethics, Financial Transactions and Fraud Schemes. Students are assisted to continue to the ACFE Board examination in order to become internationally accredited. In 2016, a new e-learning model was introduced to decrease the time spent away from the workplace, thereby encouraging more professionals to enrol.

Commitment is key driving force
Speaking at the media briefing, Jo’Anni Deacon, Senior Officer at the UFS Business School, said “by presenting the programme, the university had positioned itself as a key partner with provincial government and other entities in the fight against fraud”.

Head of Department in the Free State Provincial Treasury, Godfrey Mahlatsi, reiterated the stance of zero tolerance against fraud, and that the department was committed to ensuring that this partnership continued to grow, enabling all to strengthen the message that fraud and corruption undermined the goals and objectives of the National Development Plan.

Gerhard Geldenhuys, Director of PwC Forensic Services said: “I believe we are making a difference and further believe that the time for dialogue on fraud is now better than ever.”

The week-long campaign encourages employees (both in the public and private sector), and business leaders, to proactively take action to minimise the impact of fraud in their environments.

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