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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS Music rises to academic prominence

2007-10-18

From the left are: Ronella Jansen van Rensburg, Hanna van Schalkwyk, Elene Coetzer en Lizabé Lambrechts

Four postgraduate students gave prominence to the Music Department of the University of the Free State by having four academic articles published by accredited journals, and a fifth published in an international online journal.

It is the first time that a tertiary music institution in South Africa has had so many postgraduate studies published in one year, says Prof Martina Viljoen.

The students who worked under Prof Viljoen's supervision are Hanna van Schalkwyk, senior lecturer in singing at UFS; Ronella Jansen van Rensburg, part-time music lecturer and founder of the Sentraal-Kultuurakademie (Central Culture Academy); Elene Coetzer, also a part-time lecturer and involved in the Mangaung String Project; and Lizabé Lambrechts, who is still studying full-time.

Hanna and Ronella attained their master's degrees and Lizabé honours.

Hanna's research on the unique and at times unorthodox philosophy in singing and method of the pedagogue in singing Sarie Lamprecht (1923-2005) is published in the Tydskrif vir Geesteswetenskappe (Journal for the Humanities).

The study documents interviews held with Lamprecht over more than two years as well as conversations with her most prominent students.

Ronella's study on the relationship between emotional intelligence and musical performance anxiety is divided into two successive articles in the journal Musicus.

Dr Adelene Grobler, Epog director at UFS, was Ronella's co-supervisor.

Elene conducted a qualitative investigation into the Mangaung String Programme in which the social value of this teaching programme is emphasised.

She documented the responses of learners, parents and teachers who are involved in the project. Her article is published in the Journal of the Musical Arts in Africa.

Lizebé reached out to pop culture for her research and wrote about no less a person than the controversial shock-rock-icon Marilyn Manson.

Her study serves as a model analysis for educational work that focuses on popular culture as a didactic instrument.

In this respect Manson's music, which is frequently slated as vulgar or disturbing, is shown as aggressive social comment.

Lizabé's article, which throws light on Manson's bisexual identity, was published as a full-length monograph in the first edition of the overseas online noncejournal.

In 2005 the Department of Music also excelled when it was the first academic music institution in South Africa that published international congress proceedings as a subsidised collection.

The collection contained eminent international authors and was published under the guest editorship of Viljoen.

Die Volksblad – 1.10.07

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