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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Care centre goes high-tech to help sexual abuse victims

2016-11-25

Description: Colposcope Tags: Colposcope

The colposcope, donated by the Discovery Fund,
will be used during gynaecological examinations
to detect any irregularities.
Photo: Supplied

Rape is one of South Africa’s most pressing social problems. Rape levels in the country are often discussed and reported on, but it does not deter perpetrators from this behaviour. According to Africa Check, of the more than 42 000 rape cases reported in 2015, 15 790 were child rape cases.

In an effort to assist victims of sexual assault and rape, the University of the Free State (UFS) Department of Family Medicine adopted the Tshepong Thuthuzela Care Centre, under the leadership of UFS lecturer Dr Mariaan Kotze.

The Discovery Fund donated a colposcope to Tshepong Thuthuzela Care Centre, an instrument that works with the help of a bright light and which is used to examine victims of abuse. It has also become a standard of good practice in the assessment of child abuse worldwide. According to Dr Kotze, the new instrument will also be used for training health practitioners by rendering clinical forensic services to abuse victims.

Managing complex issues

The care centre works with between 80 and 120 victims of rape each month, a third of whom are children under 14 years of age. According to Dr Kotze, the management of child sexual abuse victims is more complex than with adults; as there is a higher chance of missing or over-diagnosing abnormalities. Also, she says, the examination process is often observed by a group of healthcare practitioners, an experience which is often intrusive and intimidating for the child. With the colposcope, the timeframe of the examination is shortened, and can be captured and viewed in real time, without the victim being present.

Best care for victims

The colposcope is a magnifier and light source used during gynaecological examinations. It is instrumental in providing the best care to victims of sexual abuse, and helps diagnose and assist in the treatment of cases of abuse. Its ability to capture and review images at the time of examination allows for retrospective research, and improves the ability of expert witnesses in court cases.

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