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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Young researchers shine during Afromontane Colloquium

2016-12-01

From the left are Drs Reetu Sogani (India),
Greg Greenwood (US-Switzerland), Teboho Manchu
(Acting Campus Principal), Drs Jianchu Xu (China),
Henri Rueff (Switzerland), Glen Taylor (Senior Director:
Research Development), and Elsa Crause
(Campus Vice-Principal: Academic and Research).

The University of the Free State’s Afromontane Research Unit (ARU), which is situated on the Qwaqwa Campus, has the potential to produce some of the world’s best and dynamic young researchers. This is the view of Dr Henri Rueff, who was one of the keynote speakers during the recent ARU Colloquium hosted at Golden Gate in the Eastern Free State.

Dr Rueff, a geographer and environmental economist from the Universities of Basel and Bern in Switzerland, was referring to no less than ten Qwaqwa Campus postgraduate students who made oral and poster presentations during the inaugural international colloquium.

“You have some of the world’s most motivated and highly skilled students who have the courage to stand in front of extremely critical scientists from all over the globe – and that must be commended,” he said.

Also talking about the students at the colloquium, was Dr Reetu Sogani from India, who said that her first trip to South Africa did not disappoint. “This colloquium was a very good learning experience for me as I had the opportunity to interact with brilliant and young scientists from this part of the world,” she added. In closing the colloquium, the Senior Director: Research Development, Dr Glen Taylor, committed the UFS to the success of the unit.

“The ARU will strengthen the research output of the campus. But most critically, it is setting the research agenda for the Qwaqwa Campus, and for the institution at large, to address the challenges that the surrounding mountain communities are faced with,” he said.

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