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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS appoints Prof Francis Petersen as Vice-Chancellor and Rector
2016-12-02

Description: Prof Francis Petersen  Tags: Prof Francis Petersen  

Prof Francis Petersen

The Council of the University of the Free State (UFS) is pleased to announce that it has decided to appoint Prof Francis Petersen as Vice-Chancellor and Rector of the UFS.

Announcing the decision to appoint Prof Petersen today (Friday 2 December 2016) during the quarterly Council meeting on the Bloemfontein Campus, the Chairperson of the UFS Council, Judge Ian van der Merwe, said the university was fortunate to be able to appoint a candidate of such good quality to the position.

Prof Petersen, Deputy Vice-Chancellor: Institutional Innovation at the University of Cape Town (UCT), and Prof Lis Lange, Vice-Rector: Academic at the UFS, were in line for the position. The university’s Selection Committee expressed equal preference for both and the two candidates were therefore recommended to Council for the position.  
 
“It has been a truly participatory and transparent selection process, which has assisted in the Council being able to make this decision. The higher-education sector has been through a difficult and challenging time during the past few months and the Council is thankful that a leader like Prof Petersen can head the university in 2017 and beyond,” said Judge Van der Merwe.

In his statement of intent, which was submitted earlier as part of the application for the post, Prof Petersen indicated that it is important to imagine the UFS’s location in South Africa and Africa, to realise the challenges within this context, now and in the future, so as to sharpen the university’s focus to become a more inclusive, academic excellent institution, embedded in a culture of innovation. “Therefore, the ideal of academic excellence must be supported by an institutional framework of diversity and inclusivity. The Academic Project should focus on a unique educational experience for every UFS student, the enhancement of student throughput-rate in academic programmes through dedicated academic support, graduate attributes, and curriculum change and renewal,” he said. He furthermore stated that research and innovation must focus on impact and international visibility. “It is thus not only the increase in research and innovation output, but the quality and impact thereof.” 

Prof Petersen was previously the Dean of Engineering and the Built Environment at UCT. He brings to the position of Vice-Chancellor and Rector his extensive experience of management in both the industry and academic sectors. He has been the executive head of strategy at Anglo American Platinum and head of the Department of Chemical Engineering at the Cape Technikon (now Cape Peninsula University of Technology). He is a member of the UCT Council, non-executive director on the Board of Pragma Holdings, non-executive director on the Board of the Unlimited Group, and Chairman of the Board of Trustees of the Seedcap (Venture Capital) Trust. Among others, he previously served as member on the Board of the Council of Scientific and Industrial Research, the National Advisory Council on Innovation, and the Council of the Academy of Science of South Africa.

He graduated from Stellenbosch University with a BEng (Chem Eng), MEng (Metal Eng), and PhD (Eng) degrees and completed a short course on Financial Skills for Executive Management. He is a recipient of the Ernest Oppenheimer Memorial Trust Award for research excellence, and was visiting professor at the Cape Technikon and extraordinary professor in the Department of Chemical Engineering at Stellenbosch University. He is a regular reviewer of journals, and member of a range of editorial boards for international journals.

Prof Petersen is also a registered professional engineer with the Engineering Council of South Africa and a Fellow of both the South African Institute of Mining and Metallurgy, and the South African Academy of Engineers. 

Prof Petersen succeeds Prof Jonathan Jansen, who stepped down as Vice-Chancellor and Rector of the UFS on 31 August 2016. An international executive search agency specialising in academic appointments has assisted the UFS Council in its search for top-quality candidates.

 

Released by:

Lacea Loader (Director: Communication and Brand Management)
Telephone: +27 51 401 2584 | +27 83 645 2454
Email: news@ufs.ac.za | loaderl@ufs.ac.za
Fax: +27 51 444 6393

 


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