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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

SAMWOP creates space for sharing research

2016-12-06

Dr Kristina Riedel, Head of the UFS Department of
Linguistics and Language Practice; middle:
Prof Nancy Kula, of the University of Essex; back:
from left, Dr Elias Malete, lecturer at the UFS
Department of Linguistics and Language Practice,
Prof Andy Chebanne, from the University of Botswana;
and Lesoetsa Motsamai, from the University of Stellenbosch,
at the SAMWOP workshop on 24 November 2016.
Photo: Rulanzen Martin

“The Southern African Microlinguistics Workshop (SAMWOP) creates space for sharing the latest research, networking and building stronger collaboration amongst linguists.”

This is what Dr Kristina Riedel, Head of the Department of Linguistics and Language Practice at the University of the Free State (UFS), said of the 5th SAMWOP hosted by her department. The workshop, hosted from 24 to 26 November 2016, also provided linguists who work on theory and language description in South Africa, the opportunity to network. “As a free conference it is very important, particularly for students and junior scholars.”

International delegates attend workshop

Participants at the workshop were from eight countries including the US, Botswana, Mozambique, Brazil and the UK. Prof Nancy Kula (University of Essex, UK), who was recently appointed as research associate to the department, presented jointly with Xiaoxi Liu, work on depressor effects (consonants which lower tones) in Bantu languages. Other presenters discussed Bantu languages, Khoisan languages and Afrikaans.

Microlinguistics analyses language and sound

“Microlinguistics focuses on analysing language data that deals with language sounds, structures and meaning, rather than language in society,” Dr Riedel said. “The range and diversity of the research on African languages presented at SAMWOP5 were a true highlight. There is a need for more research into African languages and SAMWOP presents the opportunity to scholars in the field to share their work, including in the accredited open-access proceedings.

“We are happy that we were able to hold a very successful and well-attended workshop despite the disruptions to the academic calendar this year,” the professor said.

The Linguistics Society of Southern Africa supported the cause in the form of a grant with additional support from the Office of Dean of Humanities at the UFS.

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