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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Farewell to the Class of 2015
2016-12-07

Description:Class of 2015 Tags: Class of 2015 longdesc=


Some of the students from the Class of 2015

The First Year Leadership for Change programme (F1 L4C) hosted its final graduation ceremony for the class of 2015.

Launched in 2010, the programme gives first-year students international exposure to top universities across the world, providing invaluable opportunities to explore the concepts of transformational leadership, global citizenship and social cohesion.

The 32 students and six staff mentors visited various universities which included, New York University, Rutgers University, Edmonds Community College and Washington University ­- all in the US, Mahasarakham University in Thailand and Vrije University in the Netherlands.

Making a change through critical thinking

Pura Mgolombane, Dean of Student Affairs at the University of the Free State (UFS), challenged the students to think about making a change and to critically think about themselves and how they see the world.

The graduation function, which took place on 16 November 2016, saw the class of 2015 come together to celebrate their accomplishments over the year and allowed the class representative, Tammy Fray, to reflect on all of the valuable lessons learnt.

Special announcement to end the evening

Throughout the evening, representatives from previous years testified to the impact the programme had on their personal development, leadership pathways and their learning communities. The audience was charmed with a song by Stefan Lotter, current chair of the F1 Fellowship Association, and the Delicate Artistry Band.

The evening ended with a special word by Prof Nicky Morgan, acting Rector of the UFS, who convinced by alumni’s testimonies, acknowledged what the exceptional programme had delivered over the past six years. Although it was at the end of its lifetime, he said that in review, ideas emerging from the programme should be explored to give birth to something new.  Watch this space!

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