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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Second OSM concert inspires Heidedal youth

2016-12-08

Sehle Mosole, left, and Jonandrea Pofadder back,
with the children from the ROC Foundation during the
second OSM community outreach in Heidedal, Bloemfontein.
Photo: Supplied

“The project is special because it is an event in the community, by the community.” This is what Gerda Pretorius, lecturer in the Odeion School of Music (OSM) at the University of the Fee State, said about the second music concert hosted by the OSM in Heidedal, Bloemfontein.

The concert, in collaboration with the Reach Our Community (ROC) Foundation on 26 November 2016, was a follow-up on the concept that was started last year. As part of the outcomes of the MUSE3706 module, the third-year Music Education students engage in a project in a specific environment. For this project the MUSE team, led by Pretorius and Anchen Froneman, collaborated with the ROC Foundation in Heidedal. Two third-year students in the OSM, Sehle Mosole and Jonandrea Pofadder, facilitated the event in 2016.

Long relationship between ROC and UFS

Since 2008, the UFS has successfully partnered with ROC through service-learning and community-engagement projects in which students from across all seven faculties participate. The foundation strives to address the challenges resulting from factors such as poverty, unemployment, HIV/Aids, single parenting, lack of guardianship, and physical and sexual abuse. In the Afterschool Care programme, the children engage in educational, cultural, and recreational activities.

Children who form part of the foundation’s Afterschool Care programme, showed their impressive music skills to their parents and guardians in attendance.

Spontaneous participation by community

“I was deeply touched by the spontaneous participation and appreciation of the community for art-related – in particular music and dance – events,” said Pretorius. A highlight was the community’s involvement in the event and the value it adds to the students’ organising skills.

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