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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Business Management students scoop Tata Africa Scholarship awards
2016-12-09

Description: Tata Africa Tags: Tata Africa 

From left: Mr Harneet Luther, Nomcebo Langa
(first-place winner), Palesa Makhetha and Dr Johan van Zyl.

Tata Africa celebrated the class of 2016 of the Department of Business Management at the University of the Free State (UFS) on 1 December 2016 on the Bloemfontein Campus. As part of the company’s Postgraduate Scholarship Programme, 11 academically and financially deserving students will have their postgraduate studies sponsored in 2017.

The scholarship programme was initiated by the Department of Business Management in 2012, in collaboration with Tata Africa. The aim is to provide final-year Strategic Marketing students an opportunity to apply their theoretical knowledge by developing practical marketing strategies for any one of the Tata Group companies operating in Africa.

Students were invited to present their ideas to a panel of UFS and Tata Africa representatives, who selected the category winners. The categories were for the Tata Bakkies, Jaguar vehicles, Tata Chemicals in Magadi, Kenya, and Land Rover vehicles, intended to enhance the business’ competitive edge. The top three winners were Nomcebo Langa, Internal Marketing; Johan Nel, #OutPaceThis campaign; and Jesse Heath, Entrepreneurial Development campaign.

Topics covered by the students include target market identification, development of practical marketing strategies (digital and traditional), service strategies, experiential campaigns and application design.  The Executive Director of Tata Africa Holdings, Mr Len Brand, said, “In the course of change in Africa and South Africa, in particular, we are very honoured to inspire young minds to bring innovative marketing solutions to the Tata business. We hope that their creativity will also inspire innovations in business, government, and civil society that will ultimately sell South Africa and Africa as good investment destinations.”  

Dr Johan van Zyl from the Centre for Development Support congratulated the winners and encouraged them to continue on the path of augmenting creativity in business. In presenting the awards, Executive Director of Tata Automobile Corporation SA, Mr Harneet Luther, spoke of the origins of the Tata company, its vision and the level of innovation that its founders had, which was necessary in propelling it to where it is today. He commended the students for their outstanding performance and innovative campaigns. Since 2006, over 250 scholarships have been awarded through the University of the Free State, the University of KwaZulu-Natal and Wits University.

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