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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

A year of various highlights for UFS
2016-12-19

Some other highlights:

Description: Prof Maryke Labuschagne, Bloemfontein Highlights Tags: Prof Maryke Labuschagne, Bloemfontein Highlights
The UFS was awarded five SARChI
(South African Research Chairs Initiative)
research chairs, the main goal of which is
to promote research excellence.
Read the full story


Description: Alumni Awards, Bloemfontein highlights Tags: Alumni Awards, Bloemfontein highlights

The UFS Chancellor’s Distinguished
Alumni Awards ceremony was held on
5 November 2016 on the
Bloemfontein Campus.
Read the full story


Description: Candice Thikeson, Bloemfontein Highlights Tags: Candice Thikeson, Bloemfontein Highlights

UFS student Candice Thikeson
completed a hat-trick of accolades when
she was named recipient of the Abe Bailey
Travel Bursary.

Read the full story

 

Description: Reitumetse Maloa, Bloemfontein Highlights Tags: Reitumetse Maloa, Bloemfontein Highlights

Reitumetse Maloa, a young researcher
at the UFS, is searching for a solution to
South Africa’s energy and electricity
problems from a rather unlikely
source: cow dung.

Read the full story


It was a year of various highlights for the University of the Free State (UFS) which has again illustrated the institution’s versatility by excelling on various fronts, from sports to research.

Some of these included Wayde van Niekerk winning a gold medal at the Olympic Games in Rio de Janeiro; research on the locomotion of the giraffe, and the awarding of honorary doctorates to people such as veteran journalist Max du Preez.

Van Niekerk breaks 400m world record

After his feat in Rio on 14 August 2016, Van Niekerk was described as “the next star” by former US sprinter Michael Johnson, whose 17-year-old 400m world record he broke in a time of 43,03. Johnson described the way in which the Kovsie outperformed the 400m field as “a massacre”.

Wayde van Niekerk was described as “the next star" by Michael Johnson, whose 17-year-old 400m world record he broke in a time of 43.03.


Max du Preez and Trevor Manuel honoured


Du Preez (Humanities) said he was excited about the young minds he had interacted with at the Winter Graduation ceremony of the UFS. The leading journalist and political analyst was one of four recipients of honorary doctorates from the university on June 30 2016. The others were Prof Joel Samoff (Humanities), former finance minister Trevor Manuel, and Dr Reuel Jethro Khoza (both Economic and Management Sciences.

Research of great value for conservation


Dr Francois Deacon, Department of Animal, Wildlife, and Grassland Sciences at the UFS, and Dr Chris Basu, a veterinarian at the Royal Veterinary College in the UK, conducted research on the manner in which giraffes locomote from one place to another.

Very little research has been done on the manner in which these animals move. The research will assist in understanding aspects such as the giraffe’s anatomy and function, as well as the energy it utilises in locomoting. Such information could help researchers understand where giraffes fit into the ecosystem and the data would be of great value for large-scale conservation efforts.

 

 

 

Read more on these highlights:

 

Wayde van Niekerk:

15 August 2016: Wayde the next big star, says Michael Johnson
20 September 2016: I don’t see myself as a star, says Wayde
27 October 2016: Wayde, Karla shine again at KovsieSport gala night
24 November 2016: Wayde keeps winning off the track

Honorary doctorates:

29 June 2016: UFS will award four honorary doctorates during Winter Graduation ceremonies
2 July 2016: Trevor Manuel and Max du Preez among the recipients of honorary doctorates at UFS graduation

Giraffe research:

9 March 2016: Giraffe research broadcast on National Geographic channel
23 August 2016: Research on locomotion of giraffes valuable for conservation of this species
18 November 2016: Studies to reveal correlation between terrain, energy use, and giraffe locomotion

 

 

 

 

 

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