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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Bright young mind shines
2016-12-12

Description:Candice Thikeson  Tags: Bowls  longdesc=


Candice Thikeson, a Master’s
student in Arts History and
Image Studies at the University
of the Free State.
Photo: Anja Aucamp

“I was once told that I looked ‘immaculate’, as always. We use the word ‘immaculate’ to describe the Virgin Mary, does it get better than that?”

To everyone else, she may be a Mandela Rhodes Scholar, Bright Young Mind and Abe Bailey Travel Bursary candidate, but there is more to this beauty that meets the eye.

Relating to women in the humanities field

Candice Thikeson, who is currently a Master’s student in Art History and Image Studies, says “I have a very strong spiritual foundation and my relationship with God really fuels everything I do. I also think being intentional about building great relationships with your family and friends is imperative.”

She says she has been inspired by different people at different stages of her life and draws a great deal from academics, creatives and activists. She relates best to women who are in the humanities and draws inspiration from the likes of Nigerian novelist, Chimamanda Ngozi Adichie, and Kenya-born, Somalian poet Warsan Shire.

“I love how they are able to comment on some of the most pressing issues black women face through beautiful and poignant writing. I also admire how frank these women are, something I’m still learning to be,” Thikeson says.

Pursue something you are genuinely interested in

The biggest misconception people have of her is that she studies art and she is working towards becoming an artist. “Fine art and art history is not the same thing. I don’t paint or make art at university, and I really don’t enjoy being called an artist.”

When asked about how she has become so successful at such a young age, she reiterated the cliché: “pursue something you are genuinely interested in and passionate about”. She adds, “if you are really good at what you do, your gift will make room for you in your field”.

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