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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS postdoctoral Fellow expands international opportunities for women in Science Communication

2016-12-13

Mikateko Höppener, postdoctoral Fellow at the
Centre for Research on Higher Education and
Development (CRHED), University of the Free State (UFS),
who was selected as one of five South African women
to participate in the Best Practice in Science
Communication UK study tour.

“Often, the power lies in our own hands as individuals to take the initiative, be curious about opportunities to learn, develop an interest to make a positive contribution in society through our research, and make use of our networks within and outside of academia to effect positive change.”

This is according to Mikateko Höppener, a postdoctoral Fellow at the Centre for Research on Higher Education and Development (CRHED), at the University of the Free State (UFS), who was selected as one of five South African women to participate in the Best Practice in Science Communication UK study tour. This was part of the British Council and Academy of Science South Africa (ASSAf) women in science project.

Höppener said she saw this as an opportunity to expand opportunities for women in Science, Technology, Engineering and Mathematics (STEM). “The whole experience reinforced my conviction that there is a lot of untapped potential for young people to practise and enhance science communication in South Africa for the betterment of our communities,” she said.

During her visit to the UK, Höppener was exposed to an international networking platform of science communication practitioners and stakeholders such as the Director for Development of Vitae, departments at The Royal Society, science journalists at the BBC World Service, policy advisers and public engagement teams at the Welcome Trust, the Director of SciDev.net, and the Science Adviser for STEM Education and Public Engagement at the British Council.

Höppener said each of these meetings had highly interactive presentations and discussions with members of various organisations and the South African delegation.

Being selected for the science communication fellowship and attending the study tour was not only personally and professionally rewarding for Höppener, it also enabled her to pass on what she had learnt to fellow emerging women researchers in South Africa.

Earlier this year, she hosted a WiSTEM (Women in Science, Technology, Engineering and Mathematics) Science Communication and Engagement Workshop at the UFS and through press releases and radio interviews, brought positive attention to the UFS to inspire young women across the country to get involved in science communication training.

“I intend to establish a science communication and engagement centre at the UFS where ongoing training, mentorship and support will be offered to young researchers to learn how to orient their knowledge and research to community development through science communication,” said Höppener.

The Best Practice in Science Communication UK study tour took place from 24 to 28 October 2016 as part of the Newton Fund Professional Development Programme South Africa.

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