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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS study shows playing time in Super Rugby matches decreasing
2016-12-19

Description: Super Rugby playing time Tags: Super Rugby playing time 

The study by Riaan Schoeman, (left), Prof Robert Schall,
and Prof Derik Coetzee from the University of the Free State
on variables in Super Rugby can provide coaches with
insight on how to approach the game.
Photo: Anja Aucamp

It is better for Super Rugby teams not to have the ball, which also leads to reduced overall playing time in matches.

This observation is from a study by the University of the Free State on the difference between winning and losing teams. Statistics between 2011 and 2015 show that Super Rugby winning teams kick more and their defence is better.

These statistics were applied by Riaan Schoeman, lecturer in Exercise and Sport Sciences, Prof Derik Coetzee, Head of Department: Exercise and Sport Sciences, and Prof Robert Schall, Department of Mathematics and Actuarial Sciences. The purpose of the study, Changes in match variables for winning and losing teams in Super Rugby from 2011 to 2015, was to observe changes. Data on 30 games (four from each team) per season, supplied by the Cheetahs via Verusco TryMaker Pro, were used.

About two minutes less action
“We found that the playing time has decreased. This is the time the ball is in play during 80 minutes,” says Schoeman. In 2011, the average playing time was 34.12 minutes and in 2015 it was 31.95.

“The winning team has less possession of the ball and doesn’t want it. They play more conservatively. They dominate with kicks and then they play,” says Prof Coetzee, who was the conditioning coach for the Springboks in 2007 when they won the World Cup.

Lineouts also more about kicking
As a result, the number of line-outs also increased (from 0.31 per minute in 2011 to 0.34 in 2015) and the winning teams are better in this regard.

“The winning team has less possession of the ball
and doesn’t want it. They play a more conservative
game. They dominate with kicks and then they play.”

Schoeman believes that rule changes could also have contributed to reduced playing time, since something like scrum work nowadays causes more problems. “When a scrum falls, the time thereafter is not playing time.”

According to Prof Coetzee, rucks and mauls have also increased, (rucks from 2.08 per minute in 2011 to 2.16 in 2015 and mauls from 0.07 per minute in 2011 to 0.10 in 2015). “The teams that win, dominate these areas,” he says.

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