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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Meet our Council: A teacher with a passion for changing lives

2016-12-19

Henry Dumisani Madlala

William Arthur Ward once said: “The mediocre teacher tells. The good teacher explains. The superior teacher demonstrates. The great teacher inspires.”

However, a teacher can only be great and inspire when teaching is a passion and a calling.

This is exactly the case with Henry Dumisani Madlala, Councillor of the University of the Free State. Mr Madlala is the principal of New Horizon College, a private school in Harrismith.

High educational standards and quality teaching
“New Horizon College is an independent, non-racial educational institution striving to maintain high educational standards and making quality education accessible to all. We have attained a 100% matric pass rate each year in the past six years since I became headmaster."

"My recipe is simple: teachers must teach and learners must learn.”

Mr Madlala was born and bred in KwaZulu-Natal and matriculated from Amazulu High School. Afterwards, he completed a BSc degree in Mathematics and Physics at the University of the North’s Qwaqwa Campus.

Delegate, govern, and trust
He says: “There are three key management principles which I follow as principal: delegate, govern, and trust. I give responsibilities to people, I make sure that they know what is expected of them, and in the end I trust them to carry out their responsibilities.”

His career as teacher and principal has been full of highlights on which he looks back with satisfaction.

Proud to plough back into the university
Madlala has been serving on the UFS Council since 2010 and has been part of Kovsie Alumni’s executive management since 2011. He is proud to plough back into the university in this manner.

“To me, being a Kovsie alumnus means pride, respect, discipline, and loyalty. Once a Kovsie, always a Kovsie!”

For this reason, Madlala believes that the UFS will play a major role in the country and in higher education for a long time to come.

“The UFS has been in existence for more than a hundred years and will no doubt survive for another hundred years or longer. We are indeed one of the leading universities in the country when it comes to transformation and academic excellence. The survival of the UFS is not a dream, but a reality.”

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