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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

PSP allows Dr Thom Wium to develop as an academic

2016-12-26

For Dr Matildie Thom Wium, the
rewarding part of teaching is “the
moments of synergy with a group of
students” and when she senses that she
could, for instance, help them to better
understand a music selection.
Photo: Sonia Small

Being part of the Vice-Chancellor’s Prestige Scholars Programme (PSP) has opened doors for Dr Matildie Thom Wium. She is able to better plan her research, and the overseas trips she has to undertake for this helps to develop her skills.

The senior lecturer in the Odeion School of Music (OSM) at the University of the Free State (UFS) says these are some of the advantages the PSP holds for her.

She attended two international conferences this year – in London in January, and in New York in August. Furthermore, she is working on musical analysis with Prof Timothy Jackson at the University of North Texas, US from 12 September 2016 to 31 December 2016. Prof Jackson is a research professor and was one of her PhD promoters.

Conferences contribute to her vision
“I think the PSP is a fantastic initiative,” says Dr Thom Wium, whose husband Daniël Wium is a lecturer in Astrophysics at the UFS. She says the reseach support from the PSP is amazing. “In addition, the writing retreats offered by the PSP help to set time aside during the busy semester to work on articles.”

“I think the PSP is a fantastic initiative.”

The conference in London was on operatic practice in the 19th century. In the US, Dr Thom Wium, who has been working at the UFS since 2007, also participated in a panel discussion on this topic. “It means a lot for my vision as an academic to participate in conferences where I have the opportunity to meet and exchange thoughts with the people whose work I read and cite.”

Involvement in SA equally important
However, she believes that it is equally important to stay involved locally. At the conference of the South African Society for Research in Music, which was hosted by the OSM from 25 to 27 August 2016, she presented a paper on composer Arnold van Wyk and performed a song cycle by him. She did research on Van Wyk for her PhD.

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