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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS outperforms SA higher education in EU-Saturn programme

2016-12-14

Partnering between the UFS and other institutions
makes it possible for staff and students to study abroad.
Pictured from left front, are: Mareve Biljohn (EU-Saturn
at University of Groningen), Memory Mphaphuli (INSPIRE
at University of Ghent) and Wanda Verster (EU-Saturn at
Uppsala University). Back: Moliehi Mpeli (Erasmus Mundus
at University of Leuven).
Photo: Stephen Collett

The University of the Free State (UFS) strives to invest in its staff and students and a proven example can be seen in the latest cycle of the Erasmus Mundus EU-SATURN programme.

The UFS outperformed the higher education sector over the past five years as it had more exchange scholarships than most South African universities. A total of 16 (18%) out of the 89 local scholarships allocated until 2016 were from UFS. Stellenbosch University, with 14 scholarships, was second.

University one of main roleplayers
Chevon Jacobs, Senior Officer said: “Internationalisation at the UFS is a great achievement as the university allocated all available scholarships to eligible staff and students. She said the strong partnership history between the university and some European institutions, due to a similarity between the language and culture of especially Dutch-speaking countries, is one of the reasons for the success.

“We are very proud of our participation. We have invested for these predominantly young members to spend time abroad in furthering their qualifications,” she said.

The EU-Saturn project has been jointly co-ordinated for the past five years by the University of Groningen, Netherlands, and the UFS.

One of few projects funded by Erasmus Mundus
The Erasmus Mundus is an international partnership aimed at enhancing the quality of European higher education and the promotion of dialogue and understanding between people and cultures through co-operation with other countries. The EUROSA, EU-Saturn, Aesop and INSPIRE to name a few, are all programmes funded by the European Union through the Erasmus Mundus. These projects offer fully funded part-time or full-time postgraduate scholarships for study in Europe.

Some of the universities UFS students have studied at are the University of Groningen, the University of Newcastle, England, and the University of Ghent, Belgium.

Successful UFS grantees awarded scholarships over the past five years:
•   Maria Campbell (2014 – PhD) – University of Newcastle
•   Sethulego Matebesi (2014 – PhD) – Uppsala University
•   Lindie Koorts (2016 – PhD) – University of Groningen
•   Reginald Makgoba (2013/2014 – Master’s) – University of Newcastle
•   Sanet Steyn (2013/2014 – Master’s) – University of Groningen
•   Johnathan Adams (2015/2016 – Master’s) - Göttingen University
•   Eben Coetzee (2013/2014 - PhD) – University of Groningen
•   André Janse van Rensburg (2013/2014 – PhD) – University of Ghent
•   Martin Rossouw (2013-2015 – PhD) – University of Groningen
•   Jan Schlebusch (2013-2016 – PhD) – University of Groningen
•   Carel Cloete (2014-2016 – PhD) – University of Groningen
•   Nadine Lake (2014-2016 – PhD) – Uppsala University
•   Elbie Lombard (2014-2016 – PhD) – University of Ghent
•   Luyanda Noto (2014/2015 – PhD) – University of Ghent
•   Mareve Biljohn (2015/2016 – PhD) – University of Groningen
•   Wanda Verster (2015/2016 – PhD) – Uppsala University

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