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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Researcher wins prize for her work to reduce environmental pollution

2016-12-26

Prof Danie Vermeulen, Dean of the Faculty of Natural
and Agricultural Sciences, and Josepha Zielke, a
PhD student at the Institute for Groundwater studies at the
University of the Free State.
Photo: Leonie Bolleurs

Josepha Zielke, a PhD student at the Institute for Groundwater Studies at the University of the Free State (UFS), received the prize for the best student presentation at the International Mine Water Association (IMWA) symposium in Leipzig, Germany, this year. Her paper was titled Fine Ash Leaching in Tailings Dams – An Impact on the Underlying Aquifers?

Zielke said: “It is an honour to receive this prize as a student. IMWA is a big association which allows you to establish a network with other scientists, to exchange opinions and ideas and to gain new inspiration for your own work. It was exciting and informative to hear about the research conducted around the world and to meet the researchers themselves.”

Born in Germany, Zielke always wanted to study overseas. During an exchange year in Grade 11, she visited South Africa. When she had to make a decision about in which country to complete her studies, South Africa was first choice as she was familiar with the people and the country.

Zielke joins leading institute on groundwater research in the country
She completed her BSc Hons in Geology at the Nelson Mandela Metropolitan University. After working for a year in exploration, she decided to focus her studies on water-related problems which has been a growing issue, not only in South Africa, but in many places around the world. Zielke heard that the UFS Institute for Groundwater Studies was the leading institute on groundwater research in the country, and decided to join the university.

After completing her MSc research, An analysis of the geochemical weathering profile within a fine ash tailings dam, Mpumalanga, South Africa, Zielke started the research for her PhD project on groundwater pollution along a fault system in Mpumalanga.

Research adding value to the environment by reducing pollution
She explains the focus of her research: “Several production plants and mine waste facilities are located on or near these geological structures which could be a possible cause of ground and surface water pollution. With the aid of geophysical ground surveys (using electromagnetics and electrical resistivity tomography), aquifer and tracer tests, we are trying to determine where the pollution is coming from, how far it has been distributed and to model the potential risks.

“This research will add value to the environment by preventing or at least reducing pollution leaking into the environment. Industrial sites always have a negative footprint on the environment but at least we try and contain it by finding the cause of ground and surface water pollution. Thereafter we try and solve the pollution problem or at least mitigate the damage to prevent the spreading of ground and surface water pollution in the area.”

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