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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Teaching has always been in opera singer’s genes

2016-12-26

Albertus Engelbrecht believes that his predecessor
and mentor at the Odeion School of Music ,
Peet van Heerden, prepared him wonderfully for his task
as Vocals lecturer.
Photo: Jóhann Thormählen

He has captivated audiences from Berlin to Los Angeles with his singing talent for 17 years. Yet, teaching has always been in his genes, and as a child Albertus Engelbrecht dreamed about teaching music someday.

Once, when the opera singer stood on the Free State flats during his MMus studies at the University of the Free State (UFS), he knew this is where he would come.

He has been employed as Vocals lecturer at the Odeion School of Music (OSM) since 1 July 2016 and is now ploughing back his knowledge for students he believes have an incredible passion for singing that is not found even in European vocalists.

Concerts in Los Angeles stand out
Engelbrecht was a lyrical tenor at the Landestheater Niederbayern in Passau, Germany, and was working with students as well as professional singers (in Nürnberg and later Passau). However, he was bitten by the teaching bug much earlier. “When I was a student at Stellenbosch (where he obtained his BMus degree at Stellenbosch University), I discovered I had a love for vocals training,” he says.

He has performed all over Europe and worked with famous conductors such as Philipp Augin (Los Angeles Opera). “The most impressive performance was the New Year concerts in Los Angeles, and specifically the concert in the Walt Disney Concert Hall, with fantastic architecture by Frank Gehry, and housing approximately 2 260 people.”

“When I was a student at Stellenbosch, I discovered that I had a love for vocals training.”

Big boots to fill at OSM
He achieved his master’s degree magna summa Cum Laude at the UFS and received the Fanie Beetge prize for the best postgraduate student. He studied for his master’s degree under Peet van Heerden, with Dr Matildie Thom Wium as supervisor.

Following Van Heerden’s retirement, Engelbrecht had big boots to fill. “The most important thing that I learnt from him as mentor was that the instrument of a vocalist is also the body and soul of that individual – to be able to see the human standing, singing before me.”

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