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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

#PeopleOfKovsies brimming with positivity
2016-12-26

Kovsies both young and old, whether they are currently studying or have already graduated, abound in positive energy. Striving to harness this positivity, the #PeopleOfKovsies campaign was born. Over the past three years, this campaign has garnered a collection of photographs and quotable quotes from visitors, staff, students, and alumni that showcases the feeling that only a Kovsie knows.

The process is simple: Staff photographers approach people on campus and ask whether they are willing to pose for a photo. How they do this is up to the individual’s favourite style: pouting, looking serious, pointing, or just smiling. Participants then also have the opportunity to share a brief message with the Kovsie community, whether it is just how they feel at that particular moment, what it means to them to be a Kovsie, or how they picture that indescribable Kovsie feeling. These photographs, along with their captions, are shared on our social media platforms, and, in some cases, used on campus billboards or in our publications.

Description: Retha Hill Tags: Retha Hill

“I loved being a Kovsie, because my fellow Kovsies were more than just friends   they were like
FAMILY.” - Retha Hill

Description: Keamogetswe Nnyane Tags: Keamogetswe Nnyane

“I get to enrich my community through the diversity and exposure I received as a Kovsie.
To help uplift those who can’t do the same for themselves.” - Keamogetswe Nnyane

Description: Byron Wegger Tags: Byron Wegger

“The gateway that opened my mind to different ideas as well as giving me opportunities
through sport and academics I never would have experienced anywhere else.” - Byron Wegger

Description: Tamie Mbombo_PeopleOfKovsies Tags: Tamie Mbombo

“They have succeeded in creating the conditions wherein students from disadvantaged
backgrounds can be brought to the starting line of a race that many are unaware is even
being run.”-  Tamie Mbombo

Description: Lerothodi Molete Tags: Lerothodi Molete

“It means being an agent of change. Also equipping me with skills and exposure to be the
change I want to see in the world.” - Lerothodi Molete

Description: Lebogang Kotsi Tags: Lebogang Kotsi

"To be a Kovsie means being in a multi-racial learning institution and striving to be a great
leader in the future." - Lebogang Kotsi




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