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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS congratulates Free State on matric results
2017-01-05

 Description: 002 IBP Matric results Tags: 002 IBP Matric results

With projects like the Internet Broadcast Project and the
Schools Partnership Projects the UFS helps to improve
education at schools in the Free State.
Photo: iStock

The University of the Free State (UFS) congratulates the Free State and its learners on their outstanding performance in the 2016 matric results. The university, who also plays a role in promoting excellence at school level, is proud of the Free State’s achievement as the best-performing province in the country with a 93,2% pass rate, excluding progressed learners.

“On behalf of the university community I would like to congratulate the Free State MEC of Education, Tate Makgoe, who is also a member of the UFS Council, and the Department of Education in the province on this fine achievement. The UFS is proud to be involved in projects that contribute to the success of the province’s learners. These include the Internet Broadcast Project (IBP) and the Schools Partnership Projects (SPP). The projects help to improve the quality of teaching and help learners to overcome severe domestic conditions in rural areas,” says Prof Nicky Morgan, Acting Vice-Chancellor and Rector of the UFS.

Internet Broadcast Project

The UFS IDEAS Lab in the Department of Open and Distance Learning on the UFS South Campus supports learners in 83 schools through the IBP with the help of academic videos. The project is a collaboration between the university and the Department of Education in the province. It includes support for subjects such as Mathematics, Physical Science, Life Science, Economics, Accounting, and Geography.

A purpose-built school appliance, comprising a projector, speakers, and a PC, is set up at each school, where learners receive video lectures from highly-qualified teachers.

During a function held in Bloemfontein on 5 January 2017 to congratulate performing schools in the province, Mr Makgoe made special mention of the IBP and said that part of the success of the province can be attributed to the project. Many of the top performing schools had learners who participated in the project. One of the districts that forms part of the project, the Xhariep District, was announced as the top performing district in the province, and is second in the country.


Schools Partnership Projects

The SPP focuses on teachers in order to have a more sustainable impact, with 69 schools in the Free State and Eastern Cape being part of it.

It makes use of mentors (30) who assist teachers and headmasters with school management, Mathematics, Physical Science, Accounting, and English as language of learning. The project has an annual budget of more than R15 million – all the funds come from sponsors outside the UFS.

Mentors visit schools and share knowledge, extra material, and technology to improve the standard of teaching. The change has been significant. Matric results and Bachelors pass rates have improved dramatically in these schools.

Another aspect is the identification of learners with potential (so-called first-generation students) to go to university. They are assisted through extra classes and in applying for tertiary education and bursaries.

Many of them currently study at the UFS, and also receive mentorship at university.

Dr Peet Venter, SPP Project Manager, said his team is proud to be part of the process of helping the Free State to become the number one province in the country again.

Both the IBP and SPP was started in 2011 and are managed from the university’s South Campus in Bloemfontein.

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