Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Enactus heeds call to be of service to its communities

2017-01-17

The newly-elected vice president of Enactus
University of the Free State, Solomuzi Khati
(third from left) with members of Enactus on
the Qwaqwa Campus.
Photo: Thabo Kessah

The future of South Africa is in good hands if Enactus activities are anything to go by. Enactus is an international non-profit organisation bringing together student, academic and business leaders committed to using entrepreneurial action to improve lives. And the Qwaqwa Campus chapter is doing exactly that – changing lives.

Community engagement
This team of enthusiastic and energetic students have touched the Qwaqwa community in more ways than one through their community engagement activities. One such activity was when they adopted the Team Spirit Centre as their partner for development and empowerment.

“Up to now, the chapter has lived up to its purpose of assisting and uplifting the Qwaqwa community. As part of our programme, we identified a problem that we are currently helping to solve,” said Solomuzi Khati, the newly-elected vice president of Enactus University of the Free State.

Skills development
“We have realised that many centres housing orphaned and vulnerable children, like the Team Spirit in Makoane in Qwaqwa, are not sustainable. Our project introduced a business concept to the centre where we helped to plant vegetables so the owner Mrs Manthabeleng could then use and sell at a later stage,” he said. “In the process, students and Mrs Manthabeleng would develop various entrepreneurial, finance and business skills for future use on top of the centre generating income to sustain itself,” he added.

Appointment of Advisory Board
Khati also revealed Enactus was in the process of inviting business and community leaders into their Business Advisory Board. “This is a group of business people who are recruited to serve as mentors for our team. Typically, a Business Advisory Board is composed of 10-50 business leaders in the community. Board members can keep students informed of current business concerns and trends, provide financial or in-kind assistance for projects, critique annual reports and presentations, and provide networking opportunities.”

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept