Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Freedom of religion, a constitutional right and area of global concern

2017-01-17

Prof Shaun de Freitas
Photo: Mamosa Makaya

Freedom of religion is enshrined in the South African Constitution, states that everyone has the right to freedom of religion, which more specifically entails the freedom of conscience, religion, thought, belief and opinion. It makes provision for the protection of religious communities in South Africa. Consequently, the maintenance and protection of such a right is of fundamental importance.

Prof Shaun de Freitas, Associate Professor of Law at the University of the Free State (UFS) specialises in constitutional law, with a specific focus on the right to freedom of religion, and has produced several publications in the field. The latest is titled “Transcending the Private-Public School Divide in the Context of the Right to Freedom of Religion in South Africa”, Chapter 19, in Religious Freedom and Religious Pluralism in Africa – Prospects and Limitations published by Stellenbosch University in 2016.

Prejudice a challenge in all societies
There are numerous challenges faced by religious groups around the world concerning prejudice, association with terrorism and political power and influence. Therefore, research in this field becomes important in helping to uphold the rights and freedoms of religious minority groups, to be able to foster understanding between communities.

Balancing responsibility and religious rights
His current focus is on challenges that have arisen in South Africa, more specifically pertaining to the right of medical practitioners to object conscientiously towards participating in certain medical procedures, the parameters of freedom related to religious associations and the inclusion of religious expression in public schools. These matters are also relevant to many other parts of the world (including, ironically enough, those democratic societies that endeavour to make diversity flourish).

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept