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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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Discovery in Scorpius constellation may signify clean energy for Earth
2017-01-23

 Description: Discovery in Scorpius constellation may signify clean energy for Earth Tags: Discovery in Scorpius constellation may signify clean energy for Earth

Earlier this year, a group of international astronomers
announced the discovery of an exotic binary star system,
AR Scorpii. The system is in the Scorpius constellation.
Photos: Supplied

See article on Nature’s website 

In future, stargazers and astronomers will look at the Scorpius constellation near the Milky Way with new eyes. Earlier this year, a group of international astronomers announced the discovery of an exotic binary star system, AR Scorpii. The system is in the Scorpius constellation.

Prof Pieter Meintjes, researcher in the Department of Physics at the University of the Free State (UFS), worked with four colleagues on what he describes as a “wonderful discovery”. This sensational discovery, which could lead to the production of cleaner energy on Earth, will be published in the research journal, Nature, early in 2017.

Model developed to interpret new set of measurements
The exotic binary star which was discovered consists of a red dwarf and a white dwarf revolving around each other every 3,5 hours. The binary system showed very prominent pulsations of 117 and 118 seconds respectively. The pulsations can be explained by a bundle radiation produced by the white dwarf star.

“These new observations have shown that the radiation is strongly polarised, a sign that we are dealing with synchrotron radiation here. Synchrotron radiation is produced by electrons accelerated to extremely high energy levels in the magnetic field of the white dwarf star,” says Prof Meintjes.

He developed a theoretical model to interpret a new set of measurements that was taken by the 1,9 m telescope and the 10 m SALT telescope at the South African Astronomical Observatory (SAA0).

Totally unique phenomenon could contribute to energy production on Earth
“I further indicated that the interaction between the magnetic fields of the white dwarf star and the red dwarf star induces secondary processes that specifically describe the behaviour of the radiation in the radio band and infrared band accurately. AR Sco is the first white-red dwarf binary system of which all the pulsated radiation could be explained by the synchrotron process, which is totally unique,” says Prof Meintjes.

According to Prof Meintjes, the value of the model lies in the fact that the processes which produce the radiation in AR Sco, can also be applied to produce energy on Earth.

 

Plasma reactors are based on roughly the same processes which apply in AR Sco, and with refining, it could be utilised to generate electricity in future. This will be much cleaner than nuclear energy.

 

The model developed by Prof Meintjes explains all the radiation in the system – from radio waves to X-rays – in terms of electrons accelerated to extremely high energy levels by electric fields in the system, which then produce synchrotron radiation over a very wide band of the electromagnetic spectrum.

Prof Meintjes is currently working on a follow-up article examining the evolution of the AR Sco, in other words, the origin of such a unique system and the final state towards which it is evolving. “My vision for the immediate future is therefore to develop a model for the evolution of the source concerned,” he says.

 

 

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