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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

The King’s Singers: British double Grammy winners hosted by OSM
2017-01-24

 Description: The Kings Singers Tags: The Kings Singers

The King’s Singers regularly tour in Europe, North and
South America, Asia and Australasia. The group will be
performing in Bloemfontein on 14 February 2017.
Photo: Andy Staples

The King’s Singers, the acclaimed British a cappella vocal ensemble, are coming to Bloemfontein, hosted by the Odeion School of Music at the University of the Free State, for an unmissable performance.

Concertgoers from Bloemfontein and surrounding areas have the opportunity to experience this extraordinary vocal ensemble at the Dutch Reformed Church Universitas at a concert sponsored by the Arts Trust.

Named after King’s College in Cambridge, the group was formed in 1965, and for the past 48 years, their work, synonymous with the very best in vocal ensemble performance, appeals to a vast international audience.

The ensemble has performed for hundreds of thousands of people each season, and regularly tours Europe, North and South America, Asia and Australasia. Instantly recognisable for their immaculate intonation, vocal blend, diction and incisive timing, the King’s Singers are consummate entertainers.

The group’s repertoire has evolved to become one of the most diverse and compelling imaginable. They have commissioned more than 200 works, including landmark pieces from leading contemporary composers including Luciano Berio, György Ligeti, Sir James MacMillan, Krzysztof Penderecki, Toru Takemitsu, Sir John Tavener, Gabriela Lena Frank and Eric Whitacre. They have also commissioned arrangements of everything from jazz standards to pop chart hits, explored medieval motets and Renaissance madrigals, and encouraged young composers to write new scores.

In addition to performing to capacity audiences and creating highly regarded and much-loved recordings, the King’s Singers share their artistry at numerous workshops and masterclasses around the world.  

Double Grammy award-winning artists, the group were honoured in 2009 for their Signum Classics release, Simple Gifts, and again in 2012 for their contribution to Eric Whitacre’s Light and Gold album. Recently voted into Gramophone Hall of Fame, rave reviews and repeated sell-out concerts confirm that the King’s Singers are one of the world’s finest vocal ensembles.

Watch videos of the The King’s Singers:
The King's Singers - Overture The Barber Of Seville
2016 Pioneer Day Concert with The King's Singers - Primary Medley
A Christmas Songbook by The King's Singers

Date: 14 February 2017
Time: 19:30
Place: Dutch Reformed Church Universitas, Bloemfontein
Cost: R295 per person | R268 per person for group bookings of 10+

Tickets for the concert are available at Computicket outlets (Checkers, Shoprite shops), at the door, or online.

For inquiries or more information, contact Ninette Pretorius at +27 51 401 2504.

 

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