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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

First-years excited about new life at university
2017-01-25

Description:Residences welcome class of 2017  Tags: Residences welcome class of 2017  longdesc=

First-years moved into residences at the
Bloemfontein Campus of the University of
the Free State on 20 and 21 January 2017.
Photo: Rulanzen Martin

The Bloemfontein Campus of the University of the Free State was abuzz with excitement as first-year students arrived at their new homes and residences, brimming with enthusiasm at starting a new chapter in building towards a professional career.

Although there were some mixed emotions about leaving the nest, most students were excited about the times ahead as they moved into their residences on 20 and 21 January 2017.

Student life and building a career

“I am looking forward to a new adventure, to student life and living at university. Also to build my future here,” said Veruska van Schalkwyk, as her parents, who had driven all the way from Springbok in Northern Cape, helped her unpack at Harmony residence.

Veruska, who will be studying Nursing, said she loved TV programmes like Grey's Anatomy. “Nursing has always been my passion and something I loved. I have always loved helping people.”

University provides a prosperous future

For Okuhle Gubevu, who will also be a first-year in Harmony, the UFS is the ideal place to further her career. “Out of all the research I have done, the University of the Free State is the one university that has a prosperous future for me in my ventures to become an accountant,” she said. “Because of that and because it is not too far from home, I decided on the UFS.”

Mopeli Lebohang will be staying in Outeniqua residence and is keen to work hard. “I heard the course I am studying, B Accounting, is the third toughest course at the university,” he said. “I am excited, because I like challenges.”

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