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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Top achievers arrive at UFS
2017-01-26

Description: Tshepo Thajane Tags: Tshepo Thajane

Tshepo Thajane, winner of the Kovsies
Star of Stars competition.
Photo: Eugene Seegers

Although first-year registration officially started on 23 January 2017 at the University of the Free State (UFS), the Marketing department invited some of the top-achieving matrics in the country to an event on Friday 20 January to assist them with early registration. These high-flying pupils have AP scores of 40 and above, and worked hard to get to where they are today, with driving ambition for their future.

The #StarOfStars
Tshepo ”Doctor” Thajane is the winner of the newly-established Kovsies Star of Stars competition, and as such received a full bursary from the UFS, among other sponsorships. He has enrolled in Actuarial Sciences and will be housed at the Karee residence. When asked what drew him to our university, he responds: “I just loved the university before I entered it, and I chose the UFS because of the respect I was shown.”

Friendly reception
Lendl Ontong will be pursuing his LLB in the Faculty of Law, and has obtained a place in the brotherhood of the Karee residence. The Ontong family hails from Worcester in the Western Cape. Lendl’s father, Mr Lionel Ontong, had this to say of his experience: “The staff at the UFS, especially at the admissions office, is the friendliest group of people I’ve ever come across, and helpful as well. My wife was sceptical when I told her about the friendly treatment I experienced when I phoned the university, but when she witnessed it today, she could see it first-hand. The friendliness is contagious, and even though I’m tired after the long journey, their attitude has rubbed off on me. And my wife now has the assurance that her child is going to be happy here. The atmosphere is one of homeliness. It’s fantastic! Even the netball coach introduced herself to my son and invited him to pop in for a cup of tea, and she won’t even be involved with his university journey. It meant a lot to us as parents.”

Description: Jani Gerber  Tags: Jani Gerber

Jani Gerber and her dad Jaco Gerber.
Photo: Eugene Seegers

Runs in the family

Jani Gerber is a second-generation Kovsie who hails from Port Elizabeth. She won the cultural division in the Matriculant of the Year competition in 2016 and was invited to join the UFS. According to her, she “didn’t even consider another university”.

Her dad, Mr Jaco Gerber, says: “The whole process of application and registration was very efficient and professional. Jani’s older sister, Anri, completed her MBChB at UFS last year and is currently working at the Pelonomi Regional Hospital. Jani has already been adopted by new friends in her residence. She says, “Some charming students welcomed us at the residence, and even helped out when we were unpacking.” Jani has aspirations to sing in the annual Stagedoor and Serenade Singoff competitions.

We welcome all our first-years and look forward to supporting them throughout their university journey!

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