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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS Council elects new Chairperson

2017-01-27

Description: Mr Willem Louw and Nthabeleng Rammile Tags: Mr Willem Louw and Nthabeleng Rammile

Mr Willem Louw, new Chairperson of the Council
of the University of the Free State, and Dr Nthabeleng
Rammile, new Vice-Chairperson.
Photo: Stephen Collett

The Council of the University of the Free State (UFS) elected Mr Willem Louw as the new Chairperson during a special meeting on Friday 20 January 2017. He was Vice-Chairperson of the Council since 13 March 2015. Dr Nthabeleng Rammile was elected Vice-Chairperson at the same meeting, making her the first woman in the history of the university elected to this position.

The election of Mr Louw comes after the announcement by Justice Ian van der Merwe at a Council meeting on 2 December 2016 that he will be stepping down as Chairperson on 31 December 2016.

Mr Louw has served on the Council since 11 September 2009 and was elected as member of the Executive Committee of the Council on 18 November 2011. He furthermore serves on the Council’s subcommittees for Audit and Risk Management, and Honorary Degrees.

In accepting his election as Chairperson, Mr Louw said that he appreciates the trust Council has bestowed on him. “It is a privilege and honour to lead Council and I look forward to the challenge. With the support of Dr Rammile and the rest of the Council, I endeavour to ensure that the university management is assisted in the governance of the university and that the Council plays its governance role fully at all times,” he said.

“The UFS is privileged to have Mr Louw and Dr Rammile leading its Council at such a crucial time in the South African higher-education sector. Their combined experience will be of great benefit to the university community,” said Prof Nicky Morgan, Acting Vice-Chancellor and Rector of the UFS.

Mr Louw is an Associate of the Transnet Centre for Business Management of Projects at the University of Stellenbosch Business School and a non-executive Director of Group Five Limited. He was previously Managing Director of the technology business unit and a member of Group Management at Sasol, where he worked from 1985 until 2011. He is a member of the South African Council for the Project and Construction Management Professions and a Fellow of the South African Academy of Engineering. Mr Louw received his Bachelor’s and Master’s degrees in Civil Engineering from Stellenbosch University and his MDP (Management Development Programme in Project Management) from UNISA. He is currently enrolled for a PhD in Business Management and Administration at the University of Stellenbosch Business School.

Dr Rammile has served on the Council as representative of the religious communities since 1 January 2016. She is also member of the Council subcommittees for Audit and Risk Management, and Naming. She obtained a PhD in Brand Management at the UFS, where she also lectured in the Department of Business Management from 2003 to 2014. She is a pastor at Global Reconciliation, where she is responsible for women’s ministry, community outreach projects, and multimedia.

Mr Louw will serve as Chairperson of Council until 31 December 2018, and Dr Rammile will serve as Vice-Chairperson until 12 March 2018.

Released by:
Lacea Loader (Director: Communication and Brand Management)
Telephone: +27 51 401 2584 | +27 83 645 2454
Email: news@ufs.ac.za | loaderl@ufs.ac.za
Fax: +27 51 444 6393

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