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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

First-years welcomed to the Kovsie family
2017-01-30

Description: Prof Francis Petersen  Tags: Prof Francis Petersen

Newly appointed Vice-Chancellor and Rector of the
University of the Free State, Prof Francis Petersen during
the first-year welcoming.
Photo: Charl Devenish

“How do you like my new blazer? Do you think these stripes suit me?” These were the words of the newly appointed Vice-Chancellor and Rector of the University of the Free State, Prof Francis Petersen, as he took to the stage in his #ProudlyKovsies blazer to welcome the 2017 first-years to the Kovsie family.

The event, which was also the start of the first-year Gateway Programme, took place on Saturday, 21 January 2017, and saw first-years and their parents make their way to the Red Square on the Bloemfontein Campus where they were formally welcomed.

UFS to produce world graduates
As newcomers, Prof Petersen wanted the fresh faces to feel welcome, to feel a sense of belonging. “You are now a Kovsie, and we want you to experience that Kovsie life until you graduate,” he told them.

During his speech, Prof Petersen reassured parents that the academic year would be completed and that the UFS would operate as an institution. He encouraged the students to absorb and gain knowledge and said the university would strive to ensure excellent knowledge. “At the UFS, we want to produce graduates for the world, and we need to ensure that we use our knowledge to uplift society,” he said.

Use differences to benefit from one another
KovsieFM presenters, Tshwaro Thothela and Gontse Choane played host to the gathering and Pura Mgolombane, Dean of Student Affairs, encouraged the first-years to use their differences to benefit from one another and to learn from this opportunity. “Make sure that the good that you do is for yourself, for others and for the university,” he said.

Prof Nicky Morgan, Acting Vice-Chancellor and Rector, welcomed Prof Petersen, his wife Cheslyn, and their two sons, Curtis and Clayton, to the UFS.

The newcomers also had an opportunity to visit their respective faculties and get to know the staff and facilities better.

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