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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS Professor on his new book on Boko Haram

2017-02-01

Description: Prof Hussein Solomon, Senior Professor Tags: Prof Hussein Solomon, Senior Professor

Prof Hussein Solomon, Senior Professor
in the Department of Political Studies and
Governance at the UFS and co-editor of the
book titled Understanding Boko Haram:
Terrorism and Insurgency in Africa.
Photo: Charl Devenish

Understanding the nature of the Boko Haram insurgency in northeast Nigeria is exactly what Prof Hussein Solomon from the Department of Political Studies and Governance at the University of the Free State (UFS) has set out to do.

Understanding the emergence of Boko Haram
Prof Solomon says tens of thousands of people have been killed in northeast Nigeria and neighbouring states as a result of the violence unleashed by the terrorist group. With the help of his co-editor, Prof Jim Hentz, who is an army colonel and lecturer at the Virginia Military Institute in the US, they set out to “understand the emergence of Boko Haram in a historical, sociological, economic and political context”.

In his book, titled Understanding Boko Haram: Terrorism and Insurgency in Africa, Prof Solomon “seeks to understand the emergence of Boko Haram in a historical, sociological, economic and political context”.

Book launch to take place in Chicago in the US
In his previous book, Islamic State and the Coming Global Confrontation, he analyses the origins and organisational structure of the Islamic State. Although an entirely new topic, but within the broad theme of political Islam, this book focuses more on how Boko Haram has become part of the Islamic State’s franchise in West Africa.

The book, which took more than a year to write, is based on secondary research, followed by primary documents and interviews done on the ground in Nigeria. It will be of much interest to students of terrorism and political violence, insurgencies, African politics, war and conflict studies, and international relations in general.

The official launch will take place at the African Studies Association’s annual meeting and takes place from 16-18 November 2017, in Chicago in the US.

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