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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Third NRF A-rated researcher for UFS
2017-02-03

Description: Prof Jansen, NRF A-rated researcher  Tags: Prof Jansen, NRF A-rated researcher

Prof Jonathan Jansen, senior researcher at the UFS
Faculty of Education, recently joined two other
UFS researchers as NRF A-rated researchers.
They from the left are: Profs Melanie Walker, Maxim Finkelstein
and Jansen.
Photo: Charl Devenish

The University of the Free State received its third A-rating from the National Research Foundation (NRF) when Prof Jonathan Jansen was awarded an A2-rating.

Prof Jansen is a Senior Research Professor in Education secondary research field and field of specialisation: Development education and Curriculum theory at the UFS Faculty of Education and Fellow at the Center for Advanced Studies at Stanford University in the US.

Prof Jansen’s rating follows P-rating
Prof Jansen’s rating also adds to the recent P-rating awarded to Dr Daniel Spence, a postdoctoral Research Fellow at the International Studies Group. In receiving the rating, the UFS became the only university in South Africa with a P-rated researcher in History.

P-ratings are given to young researchers, usually under the age of 35, who have the potential to become leaders in their field. Researchers in this group are recognised by all, or the overwhelming majority of, reviewers, as having demonstrated the potential to become future international leaders. 

“Obtaining another A-rating is indicative of the university’s drive to enhance its research profile – nationally as well as internationally. I am thankful to our scholars for their commitment to the rating process and look forward to receive the results of this year’s ratings,” said Prof Corli Witthuhn, Vice-Rector: Research at the UFS.   

Total number of researchers increased
The UFS has also upped the ante with regards to its total number of NRF-rated researchers during the latest rating and evaluation with an increase from 127 in 2015 to 149 rated researchers in 2016.

In 2015, Prof Maxim Finkelstein from the Department of Mathematical Statistics and Actuarial Science, and Prof Melanie Walker, Senior Research Professor and Director of the Centre for Research on Higher Education and Development, were given A-ratings.

Prof Finkelstein’s rating then made him the only A-rated researcher in ‘Probability and Statistics’ regarding Mathematical Sciences in the country. Prof Walker was evaluated and graded in the division for Research, Innovation Support and Advancement.

According to the NRF, A-rated researchers are “unequivocally recognised by their peers as leading international scholars in their field for the high quality and impact of their recent research outputs”.

 

The rating of individuals is based primarily on the quality and impact of their research over the past eight years.

 

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