Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Farmers need to plan grazing better, says UFS expert

2017-02-21

Description: Prof HO de Waal Tags: Prof HO de Waal

Prof HO de Waal, affiliated researcher
at the University of the Free State,
says farmers should save grazing
during the summer months to have
fodder available in the winter and
early spring.
Photo: Theuns Botha,
Landbouweekblad

“Farmers should save veld during the summer months to have grazing available for animals especially in the winter and early spring. Farmers should also adjust livestock numbers timely and wisely according to the available material in the field,” says Prof HO de Waal, professional animal scientist and affiliated researcher in the Department of Animal, Wildlife and Grassland Sciences at the University of the Free State.

He offered this advice as a result of the sporadic and scattered (scant) rainfall of the past couple of summers. “In retrospect we know that this kind of precipitation started in about 2014 and has continued in subsequent summers. In February 2015, it was clear that a major fodder scarcity was developing.”

Existing research methods serve as source of current knowledge
Dr Herman Fouché (Agricultural Research Council) has conducted research on the impact of climate, especially rainfall, on the growth of grass. Sophisticated computer technology developed as far back as the 1980s to – through modelling – predicts the impact of climate on field production during the growing season.

The impact of climate, and more specifically rainfall, on field production has been known to animal and grazing scientists for a long time. Prof De Waal used the modelling results to determine the impact of rainfall on grass as a feeding source for animals.

“Information that emerged from this old research programme could therefore be applied directly to animal production,” says Prof De Waal.

Adjust livestock numbers to availability of grazing
In the summer rainfall areas of South Africa, grass usually grows from the end of August and early September. The growth process is dependent on the transfer of soil moisture, as well as on rainfall during the winter and early spring.

“Livestock numbers should be balanced throughout the year (according to the nutritional needs and production of the animals) with the availability of grazing material – be consistent, not only during certain seasons or when drought is imminent,” is Prof De Waal’s advice to farmers. “Farmers are also encouraged to carefully reduce the number of livestock on grazing and to rather focus their attention and limited resources on the remaining breeding herds (cows and ewes).”

“It is tragic, but unfortunately many farmers will not survive the effects of recent years. Similar climatic conditions will occur, with the same tragic consequences for man and beast. Better planning has to start now.” The assistance of private institutions, individuals, as well as the government, during the severe droughts is gratefully acknowledged.

Spineless cactus pear as solution for scarcity of animal feed
Prof De Waal says spineless cactus pears could be used as a feeding source during droughts. “The effects of a severe drought, or major animal-feed scarcity, are still prevalent in large parts of the subcontinent.” This may act as a catalyst to utilise spineless cactus pears as a feeding source and to be incorporated in the feed-flow programme for livestock on natural grazing.

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept