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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Japanese researcher engages students on border issues
2017-03-02

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From the left: Dr WP Wahl, Tungamirai Kufandirori,
Sayaka Kono, Eddie de Wet and Emme-Lancia Faro
at the first academic conversation of 2017, hosted
by the Student Communities Office.
Photo: Eddie de Wet

How can we ensure humanity across borders – even if they don’t truly restrict us?

This was one of the discussions at the first academic conversation of 2017, hosted by the Student Communities Office, a division of Student Affairs. The discussions included the issue of Lesotho’s incorporation into South Africa, focusing on how ethnicity has mattered in ongoing arguments.

Basotho ethnicity

Students and staff were invited to engage with Sayaka Kono, a research fellow at the Department of Historical Studies at National University of Lesothoa, and guest speaker, on 14 February 2017 in the Equitas Senate Hall on the Bloemfontein Campus. The topic was Reconsidering Border Issues in Africa: Ethnicity, apartheid and the political independence of Lesotho.

Kono completed her Bachelor’s and Master’s degrees in International and Cultural Studies at Tsuda College in Japan. Her research interests lie in the area of ethnicity and she is currently completing her PhD on Basotho ethnicity and the former Bantustan system in South Africa.

Legacies of colonialism

A series of academic conversations was started in 2016 and aims to get top academic achievers and leaders to rub shoulders with renowned international scholars and leaders. This investment hopes to create a sense of responsibility to stretch boundaries and get the engagement culture flowing at the UFS.

According to Kono, borders of African countries are one of the living legacies of colonialism. They have reshaped the local society in various ways such as causing ‘ethnic’ or natural resource conflicts. The aim of her research is to reconsider these border issues in Africa through the perspective of ethnicity in the eyes of Basotho who have been divided by the border with South Africa for more than 100 years.

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