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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Famelab, the Pop Idols of science communication

2017-03-09

Description: Famelab Tags: UFS, CUT, Science, Competition, research, British Council, Famelab, NRF

Oluwasegun Kuloyo and Zanele Matsane proved to be
Bloemfontein’s young and wittiest science researchers.
They will represent the Free State at the Famelab
national semifinals in Johannesburg.
Photo: Oteng Mpete

Imagine sharks with laser beams attached to their heads and enzymes that wear coats, and yeasts that stage a coup d’état in your body when agitated. This was all explored at the FameLab Science Communication Competition.

Hosting the FameLab regional competition was a collaborative effort between Dr Mikateko Hoppener, from the University of the Free State’s (UFS), the Centre for Research on Higher Education and Development (CRHED), and Edith Sempe from the Central University of Technology (CUT), Research and Development Unit. Taking place for the first time in the Free State, the event was held at the UFS Centenary Complex on 2 March 2017.

Witty minds make science fun
FameLab is a competition that promotes science and technology by creating a space for scientists to find their voices and reach public audiences. The Free State regional competition had 18 contestants and two emerged victorious on the day. Contestants had to ensure their three-minute talks were fun, charismatic, clear and entertaining.

The two regional winners were Oluwasegun Kuloyo, a PhD student with the department of Microbial Biochemical and Food Biotechnology at UFS, and Zanele Matsane, a Construction Management PhD student at CUT.

Kuloyo's research deals with the management of the candida yeast which exists in most people’s bodies and which, with a healthy immune system can be kept under control, but when an immune system is compromised, the yeast reacts volatilely and can potentially lead to death in HIV/AIDS patients.

Matsane’s research is centred on collaborative construction management inspired by the Toyota manufacturing process. She hopes to resolve the silos of construction and bring about a more harmonious and fluid process to construction projects, thus ensuring their successful completion.

The panel of judges consisted of Oteng Mpete UFS Media Liaison Officer, Dr Elizabeth Conradie from the CUT Innovation Hub, and Prof Willie du Preez from the CUT Centre for Rapid Prototyping and Manufacturing, as well as Robert Inglis from JiveMedia Africa.

Local scientists become jet-setters
The two regional winners will head to Johannesburg to compete at the FameLab national semifinals, and the South African winner will go on to compete against winners from over 30 countries on an international stage, at the Cheltenham Science Festival in the UK.

FameLab is a programme of the Cheltenham Science Festival and is implemented locally by the South African Agency for Science and Technology Advancement (SAASTA), the British Council, and JiveMedia Africa. The competition has been running in South Africa for the past five years.

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