Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Student Council welcomes international students on campus
2017-03-16

Description: International students on Qwaqwa Campus  Tags: International students on Qwaqwa Campus

Some of the guests and International Student
Council (ISC) members during the welcome
function. From the left are: Tatenda Goche (Deputy
Chairperson), Loice Nzombe (Chairperson),
Bulelwa Moikwatlhai (Office of International
Affairs), Jennifer Ashafa (Secretary), and
Takudzwa Nyamunda (Chairperson on the
Bloemfontein Campus)
Photo: Thabo Kessah

SRC President Njabulo Mwali says that the presence of international students on the Qwaqwa Campus is very welcome as it enables students from all over the world to learn from each other.  He was addressing the International Student Council’s welcome function for international students.

“One important area where South African students can learn a lot from international students is hard work. It is an open secret that many of us, as South Africans, are not as persistent as we should be. We give up easily,” he said to an audience of students mainly from Zimbabwe, Kenya, Ethiopia, and Nigeria.

Speaking on behalf of the Rectorate, the Registrar: Systems and Administration, Dr Karen Lazenby, assured international students that the UFS is committed to their emotional and physical wellbeing.

International students face various challenges

“Having been an international student myself, I fully understand your various challenges. If you have any ideas on how we can make your stay here as memorable as possible, please help us to help you,” she said.

Both Drs Elsa Crause and Dipane Hlalele, respectively Campus Vice-Principal: Academic and Research and Acting Campus Vice-Principal: Support Services, congratulated students on choosing the Qwaqwa Campus.

“Our campus will give you many opportunities to reinvent yourself both as a person and a student,”   Dr Crause said.

Dr Hlalele added: “International experience is fascinating as it does not only provide different types of knowledge and truth, it also enriches the campus with an African and international footprint.”

The Office of International Affairs also presented its services to students.

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept