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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Predation Management Centre helps stock farmers to address predator problem

2017-03-29

Predators, including caracal and foxes, are costing the
livestock industry about R2 billion annually. The
Predation Management Information Centre was
established to collect, analyse, and make information
available on predation and predation management to
stock and game farmers.
Photo: Pixabay

Predators are costing the livestock industry about R2 billion annually. To address the problem, the Department of Animal, Wildlife and Grassland Sciences at the University of the Free State (UFS) teamed up with the Predation Management Forum (PMF).

Predation Management Information Centre established
The UFS has signed service agreements for the establishment of a Predation Management Information Centre with the four industries (wool, mohair, red meat, and game industries) forming part of the PMF. The centre will collect and analyse information on predation and predation management. This information will then be made available in a management information system and information contained in the system will be made available to all users.

Centre makes essential information available
At the information centre, a team of dedicated staff members handles calls and enquiries. Experts in the team are also available to provide advice to farmers. Furthermore, the centre is responsible for the management of information and resources. Relevant policy documents and scientific articles will be stored in an archive at the centre which will also collect research, statistics, biometric information, and information on new research topics.

The information that is collected will be used to assist farmers with predation management. Information on methods which are effective in a specific situation will be made available to farmers in order to help reduce predation on their farms. “By focusing on non-lethal methods in predation management, best practices can be compiled in order to restrict losses attributed to predation to the minimum,” says Quinette Kruger from the information centre.

Contact details for authorities and specialists managing damage-causing animals will also be provided by the centre.

The information centre invites stock farmers, game farmers, the general public, retail, authorities, and other stakeholders to contact the centre at +27 51 401 2210 or PredationMC@ufs.ac.za.