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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

National 3MT competition held at UFS

2017-03-29

The two winners of the Three minute thesis
competition, Andrew Verrijdt (left) and
Kerryn Warren (right).
Photo: Charl Devenish

From Neanderthal hybrid children to eating corn silk as a way of managing kidney diseases, the National Three Minute Thesis competition (3MT) captivated the mind.

“We brought the competition to South Africa and hosted the local, regional, and national competitions for the past few years,” said Dr Emmie Smit, organiser of the event. It is an opportunity to raise the profile of postgraduate research and to develop a cross-disciplinary student community to effectively communicate research to a wide audience. The event was founded by the University of Queensland, Australia. The third national 3MT competition took place at the University of the Free State (UFS) on Friday 24 March 2017.

Three minutes and one slide
During the competition, participants had three minutes to explain their master’s or doctoral research and one static PowerPoint slide could be used. “It is very important that this slide works for you. There must be some way the information on the slide connects to what you present,” said Dr Henriette van den Berg, Director of the Postgraduate School at the UFS.

Winners grateful for opportunity
“It is an honour and a drive. It is very nice to have this sort of thumbs up,” said Kerryn Warren, winner of the Science category. Her research title was, What did a Human-Neanderthal Child Look Like? “I have been looking at the hybrids between different species and subspecies of mice in order to use them as a model to find out what human hybrids looked like.”

The presentation by Andrew Verrijdt, winner of the Humanities category, entitled Hiding in the Deep: Anonymous Websites for Paedophiles on the ‘Darknet’, gave a glimpse into the mysterious and dangerous realm of the dark web. “I am grateful for the opportunity. Primarily because I think it’s an important topic, and society will benefit by getting the word out there as it is a sensitive topic,” he said. The two winners, both from the University of the Cape Town, won R15 000 each. A further R30 000 of prize money went to the four runners-up.

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