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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

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NASA Deep Space Navigation engineer presents at Naval Hill Planetarium

2017-03-30

From the left: Chris du Plessis; US Consulate, Johannesburg,
Prof Petrus Meintjes; Dept of Physics UFS, Christopher Jacobs;
NASA, and Anthony Deaton; US Consulate Johannesburg.
Photo: Rulanzen Martin

The University of the Free State (UFS) hosted NASA Deep Space engineer Christopher Jacobs on 27 March 2017 at the Bloemfontein Campus. The engagement was hosted by Prof Matie Hoffman of the Department of Physics and the Department of Institutional Advancement, in collaboration with the US Consulate General in Johannesburg.

Jacobs is stationed at NASA’s Jet Propulsion Laboratory (JPL) at the California Institute of Technology and has served as the Reference Frame Calibration task manager for 25 years. In this role he has been responsible for delivering the reference frames used to navigate NASA missions such as the Mars Science Laboratory to planetary targets.

His visit to the UFS included a presentation to the Department of Astrophysics at the Faculty of Natural and Agricultural Sciences and at the Naval Hill Planetarium in Bloemfontein where he spoke on Stellar GPS: Navigating the Solar System. He also spoke about the latest research and developments at NASA in Astrometry. The visit will establish and develop shared interests and possible collaboration with UFS and other institutions of interest in the country. “South Africa, because of its well-placed geographic location in the southern hemisphere, holds a lot of answers to astronomy,” Jacobs said.

He has an active interest in professional and public education, and outreach, having given public lectures around the world. “Astronomy brings people together and is a point of common interest that is key in solving environmental and geographical challenges such as climate change, therefore global cooperation is important,” he said.

Prof Hoffman welcomed the initiative by the US Consulate and the possible outcomes of joint efforts to position the UFS as a key partner in South Africa on NASA’s astronomy projects. In the coming weeks Jacobs will speak at high schools in Gauteng including the Mae Jemison US Science Reading Room in Mamelodi, Pretoria, a centre that is focused on promoting science education.

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