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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

State of our campuses: UFS Qwaqwa Campus temporarily closed until 18 April 2017

2017-04-03

The senior leadership of the University of the Free State (UFS) has decided to close the Qwaqwa Campus on Tuesday 28 March 2017 due to student protests regarding provisional registrations. Academic activities will resume on 18 April 2017.

The protests were preceded by a meeting of the campus management with the Student Representative Council (SRC) on 22 March 2017 to discuss issues pertaining to students who are provisionally registered – especially those students who are provisionally registered and awaiting the outcome of their appeals to the National Student Financial Aid Scheme (NSFAS).

On 27 March 2017, the SRC handed a memorandum to the campus management, requesting assistance in cases that are on appeal with NSFAS. The students also demanded extension of the provisional registration deadline of 31 March 2017, and that a fundraising plan should be implemented for financially needy students. The campus management made a commitment to respond within the deadline stipulated in the memorandum.

After the meeting, violence erupted when a group of students started intimidating students, barricading the entrance to the campus, and damaging university property. An interdict was served by the Sheriff later the same afternoon and additional security was deployed. On 28 March 2017, the violent protests and barricades spilled onto the provincial road to Phuthaditjhaba and several cars were damaged. This led to the arrest of a number of students by members of the South African Police Service for the contravention of the High Court order and for public violence. The students have since been released.

Due to the imminent threat to the safety of staff and students on the campus, the senior leadership decided on 28 March 2017 to evacuate the residences and to close the campus temporarily until 18 April 2017.

“It is unfortunate that the students resorted to violence without waiting for the campus management’s response to the memorandum of 27 March 2017. What makes the situation difficult is the fact that students on provisional registration who are waiting for the outcome of their NSFAS appeals, are dealing directly with NSFAS. This makes it difficult for the university to intervene,” says Mr Teboho Manchu, acting Principal of the Qwaqwa Campus.

The senior leadership of the UFS is aware of the video clip on social media this week, where a student is allegedly beaten by security guards on the Qwaqwa Campus. The senior leadership condemns this deplorable incident. An investigation is underway to determine the nature and cause of the incident. Appropriate steps will be taken once the outcome of the investigation is available.

Released by:
Lacea Loader (Director: Communication and Brand Management)
Telephone: +27 51 401 2584 | +27 83 645 2454
Email: news@ufs.ac.za | loaderl@ufs.ac.za
Fax: +27 51 444 6393

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