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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Boyden observatory celebrates its achievements
2004-10-05

The red carpet will be rolled out and champagne glasses filled tonight when the Boyden Observatory outside Bloemfontein will launch the first phase of the new science centre.

This phase, which was completed earlier this year, consists of a new auditorium, reception area and paths which connect educational visiting points on the Boyden terrain.

“Over the past two years the Boyden Observatory has been re-sited as a research, educational and public facility. The new facilities are now being utilised for educational and public programmes. The 1,5m Boyden telescope has also recently been upgraded and is used for research purposes,” says Dr Matie Hoffman from the University of the Free State’s (UFS) Department of Physics, who is responsible for the management of the centre.

“The Boyden Observatory is a unique facility of the UFS - we are one of the few universities in the world who has its own observatory,” says Dr Hoffman.

“The main purpose of the science centre is to create enthusiasm for science amongst the public. The centre also has a great educational function and focuses specifically on the improvement of the quality of science education in the Free State,” says Dr Hoffman.

Fund-raising for the planned second phase of the science centre, which will consist of interactive in- and outside exhibition areas, will also start tonight. “After the completion of the second phase the Boyden Observatory will probably become the most accessible and public-friendly observatory in the country and a great asset for the Free State Province,” says Dr Hoffman.

A small robotic telescope, which will be controlled from the University College Dublin in Ireland, will also be installed at the Boyden Observatory this year.

“Just as this year is a significant one for the UFS with its centenary celebrations, so it is also a significant one for the Boyden Observatory. The Harvard University in the United States of America started with the construction of the original 1,5 m telescope in its original form 100 years ago, the telescope was put in place at Boyden 70 years ago and Mr Uriah Boyden – the person who donated the money with which the Boyden Observatory was constructed, was born 200 years ago,” says Dr Hoffman.

The first phase of the science centre was built with funds sponsored by the AngloGold Fund, the Shuttleworth Foundation, the Charl van der Merwe Trust and the Lila Theron Trust. Donations from the Friends of Boyden Observatory and other individuals also contributed to the success of the project.

Those who are interested in educational tours of the science centre can contact Dr Hoffman at (051) 401-2322.

Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
5 October 2004

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