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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Suspect in theft of computer equipment arrested

2007-11-16

A suspect, who may be involved in the recent theft of computer equipment from buildings on the Bloemfontein campus of the University of the Free State (UFS), has been arrested.

On 13 November 2007 an alarm in the Agriculture Building on the Main Campus of the UFS was activated. Protection Services reacted to the alarm and the person, who tried to run away, was pursued and later arrested.

The suspect was handed to the South African Police Service (SAPS). Currently SAPS is conducting an intensive investigation in co-operation with Protection Services at the UFS.

“The extent of the investigation goes beyond this single case for which the captive was arrested,” said Mr Willie Frankim, Manager: Protection Services at the UFS.

Meanwhile, the UFS’s Safety Committee has decided on a number of measures to heighten security on campus, including:

Patrols between buildings are to be intensified.
Vehicles leaving the campus will be searched. This is being done on an ad hoc basis at all the gates.

According to Mr Frankim the university is also looking at extending the alarm system and measures to secure buildings on campus.
He said: “The above will not happen overnight. We request all staff members and students to give their co-operation and to be more security conscious by:

Giving their co-operation at the gates when their vehicle is searched,
To ensure that the windows of your office and building are closed,
To lock office doors when you leave the office, even if it is for a short while,
Not to leave your office unattended when there are strangers,
to report suspicious persons as soon as possible to Protection Services,
To ensure that valuable articles (laptops and cell phones) are locked away,
To ensure the safekeeping of keys (not in drawers or on top of a door frame), and
Determine who has access to a building and question anybody unknown.”

Contact Protection Services at any of the following numbers:

Duty room: O51-4012634 / 051-4012911

Mr Aggrey Litseho (investigation officer): 051-4013225 / 0836347919 /
Short cell phone x6060

Mr Willie Frankim (manager): 051 401 3438 / 0828831760/
Short cell phone x6000

“We can only combat crime if everybody is aware of their environment, everybody adheres to the basic rules and co-operates with Protection Services,” said Mr Frankim.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
15 November 2007

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