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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS opens centenary complex
2004-10-12

Today, 12 October 2004, the University of the Free State (UFS) opens the Centenary complex on the grounds of the old Reitz dining hall.

Me Edma Pelzer, Director: Physical Resources and Special Projects at the UFS, said the Centenary complex is furnished mainly for personnel and alumni, just as the Thakaneng Bridge was primarily established as gathering place for students.

On 10 March 2004 the UFS management held the first official function in the half completed complex during the unveiling of the memorial stone by the Rector, Prof Frederick Fourie. What made this occasion remarkable is that old President FW Reitz, 81 years earlier, on 10 March 1923, also laid a memorial stone at the same place, said Ms Pelzer. The complex originally existed of the Reitz dining hall, which was named after old president Reitz, a hostel father residence and administration offices. In historical documents about old president Reitz it is mentioned that already as chief judge he campaigned for the establishment of a university in the Free State and later as president he proceeded with this attempt.

With the opening of the Thakaneng-bridge food preparation and -serving at the Reitz dining hall was discontinued. The kitchen and dining facilities became obsolete. With the evacuation of the old student centre replacements for the Bloemfontein- and Anlgo American-rooms were to be found elsewhere on campus. The idea to convert the historical Reitz building complex in an UFS reception and a space for socialising started to exist.

Ms Pelzer said the UFS is committed to treat its history and its old buildings with respect and to utilise it optimally to enhance the strategic objectives of the university. The Centenary complex must communicate the university as an established, quality institution with an interesting history to visitors. It must serve as a home for alumni and as a one stop visiting point for important visitors who do not have time to experience the whole campus.

In the complex provision is made for entertaining and kitchen facilities, a museum where valuable UFS-memorabilia are kept and exhibited, an amfi theatre and an art gallery which would for the first time offer a permanent home for the art collection of the UFS. Venues will accommodate groups from between 15 to 300 persons.

The reception area will be used by the UFS for occasions such as chancellors’ functions, smaller and bigger receptions for the rector, tea parties after graduation ceremonies, openings of conferences and long service awards. The university also plans to rent out the complex for prestige occasions where the UFS personnel and alumni are involved.

The opening of the Centenary complex form part of the Centenary celebrations of this week. Many of this week’s activities will take place in the complex.

Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
12 October 2004

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