Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Department at the UFS receives special visitors
2008-02-26

 

From the left are: Prof. Hans Ausloos, Prof. Bénédicte Lemmelijn, and Prof. Fanie Snyman (Head of the Department of Old Testament at the UFS). Both Prof. Ausloos and Prof. Lemmelijn are professors in the Old Testament within the Bible Science Investigation Unit of the Katholieke Universiteit Leuven in Belgium.
Photo: Lacea Loader
 

Department at the UFS receives special visitors

The Department of Old Testament in the Faculty of Theology at the University of the Free State (UFS) has for the first time received a visit from two guest professors from the Katholieke Universiteit Leuven (KU) in Belgium who are presenting undergraduate lectures.

What makes the visit even further unique is that the guest professors are a married couple who specialise in the Old Testament.

“Proff. Hans Ausloos and Bénédicte Lemmelijn are visiting the faculty for about a month to present undergraduate programmes. They are part of a co-operative agreement between the UFS and the KU Leuven. This is also a good way of giving our students exposure to European experts,” says Prof. Snyman, Head of the Department of Old Testament at the UFS.

The couple and their three children, Matthias (10), Elke (8) and Ruben (6), are staying in Prof. Daan Pienaar’s house for the duration of their stay. Prof. Pienaar is a retired professor in Biblical Science at the UFS. The children are at school in Universitas Primary School for the duration of the family’s stay in Bloemfontein. “The headmaster was very kind and provided them with school uniforms out of the school’s second hand clothing shop, of which they will not part easily as they do not wear school uniform in Belgium,” says Prof. Lemmelijn.

Proff. Lemmelijn and Ausloos cannot stop talking about the charm of the university’s Main Campus. “In Leuven the university is part of the city and the university buildings are situated amongst the city buildings. We do our shopping while the students move from one class to the other! Here, the university is a town on its own and the students are given the opportunity to socialise in a protected environment,” says Prof. Lemmelijn.

The couple is also just as impressed with Bloemfontein. “The safety issue in South Africa is accentuated in such a way in Europe that we are astounded by the peaceful and friendly atmosphere of the city. We are also surprised with the shopping centres that are under one roof. In Belgium the shops are situated far apart,” says Prof. Lemmelijn.

The couple finds the living costs – especially food – to be quite expensive. “Some basic food is even more expensive than it is in Belgium,” says Prof. Ausloos.

Over and above their commitment to lecture, the couple is also busy with research on the Greek translation of the 12 Small Prophets in co-operation with Prof. Snyman.

“This is the first time that lecturers from the KU Leuven visit the Department of Old Testament for such a long time and are part of the normal curriculum. It is interesting to note that the teaching modules between the two departments resemble each other in such a way that lectures which are presented in Leuven are also repeated here,” says Prof. Snyman.

Both Proff. Ausloos and Lemmelijn are professors in the Old Testament within the Bible Science Investigation Unit of the KU Leuven. They publish articles internationally on the editorial and text criticism of the Old Testament and are involved with international investigative programmes such as the Hexapla Project and Septuaginta-Deutsch. Prof. Ausloos is director of the Leuvense Centre for Septuagint Studies and Textual Criticism and Prof. Lemmelijn is an associate in the centre. Together they have published several financed investigative projects on the characterising of the translation technique of the Greek Bible translation.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
25 February 2008
 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept