Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Famous mineralogists visit UFS Geology

2017-04-25

From the left: Prof Marian Tredoux, Associate
Professor at the UFS Department of Geology;
Prof Giorgio Garuti; from the University of Leoben,
Dr Federica Zaccarini, also from the
University of Leoben and Dr Freddie Roelofse,
Head of the Department of Geology at the UFS.
Photo: Rulanzen Martin

Years of academic friendship and collaboration is what makes Prof Giorgio Garuti and Dr Federica Zaccarini return to the University of the Free State (UFS) every so often.

The world-renowned academic duo from the University of Leoben in Austria were guest lecturers at the UFS Department of Geology. “We are here because we have known Professor Marian Tredoux and the Geology Department, for a long time. We are really happy to be here, and to be given the opportunity to present talks,” said Dr Zaccarini. The two are experts in platinum-group element mineralogy and each has given their surname to minerals namely, the Garutiite and Zaccariniite minerals.

Visit great advantage for research
They are acclaimed experts on very small minerals (smaller than a hundredth of a millimetre) with emphasis on platinum group elements in chrome-rich rocks. “Their visit is a great advantage for us. We also conduct research on these minerals and can learn from them,” said Prof Marian Tredoux, affiliated researcher at the Department of Geology.

Dr Zaccarini gave a lecture on Chromitites, and associated platinum-group elements, in ophiolites on Wednesday 5 April 2017 and Dr Garuti presented a lecture on Uralian-Alaskan complexes: a puzzling source of platinum, on Thursday 6 April 2017. During the talks they examined the association of the platinum-group minerals with chromite, rather than sulphide, and how this association can lead to the formation of unusual platinum-group element ores.

Collaboration on various academic papers
They and Prof Tredoux have collaborated on various research articles over the past four years, which have been published in various important international scientific journals. “These journals play an important role in calculating the H-scale which measures how important a researcher’s work is on an international scale,” said Prof Tredoux.

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept