Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

New publication on groundwater remediation soon to be introduced
2017-05-05

Description: Prof Abdon Atangana groundwater remediation Tags: Prof Abdon Atangana groundwater remediation

A new book from Prof Abdon Atangana from
the UFS Institute for Groundwater Studies
proposes new techniques for groundwater
remediation, including guidelines on how chemical
companies can be positioned in any city to avoid
groundwater pollution.
Photo: Pixabay

A new publication, Fractional Operators with Constant and Variable Order with Application to Geo-Hydrology, will be published later this year, on 1 November 2017. The author, Prof Abdon Atangana, from the Institute of Groundwater Studies at the University of the Free State, said the book proposes new techniques for groundwater remediation, including guidelines on how chemical companies can be positioned in any city to avoid groundwater pollution.

Focus of the book
Prof Atangana said researchers and practitioners interested in groundwater modelling and remediation from applied mathematical and geo-hydrology backgrounds, will benefit from reading this book.

According to Elsevier, the book provides a physical review of fractional operators, fractional variable order operators, and uncertain derivatives to groundwater flow and environmental remediation. It presents a formal set of mathematical equations for the description of groundwater flow and pollution problems using the concept of non-integer order derivative. Both advantages and disadvantages of models with fractional operators are discussed.

“Researchers and practitioners
interested in groundwater modelling
and remediation from applied
mathematician and geo-hydrology
backgrounds, will benefit from
reading this book.”

About the author
Prof Atangana specialises in applied mathematics, groundwater modelling, fractional calculus and their applications, methods for partial differential equations, methods for ordinary differential equations, iterations methods, asymptotic methods, perturbations methods, and numerical method for fractional differential equations, uncertainties analysis. He has participated in 18 international conferences, organised six special sections and symposiums in international conference in Europe, Africa, Asia and USA, and has been invited as plenary speaker in eight international conferences. He also serves as editor on 20 international journal of mathematics and applied mathematics and editor-in-chief of two international journals of applied mathematics.

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept