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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Prof Steyn to receive Jan H Marais Prize in Stellenbosch

2017-05-09

Prof Jaap Steyn, who started his career as
journalist at Volksblad, later entered the academy,
and was a professor at the University of the
Free State for many years.
Photo: Marthie Kemp

Although Prof Jaap Steyn will be honoured officially for his contribution to Afrikaans as an academic language at the end of this month, he only became aware of his nomination after he had won the award.

According to this research fellow in the Department of Afrikaans and Dutch, German and French at the University of the Free State (UFS), he is grateful for the recognition. He has recently been awarded the Jan H Marais Prize for his outstanding contribution to Afrikaans.

Former Kovsie honoured together with Prof Jan van der Watt
According to a statement by the South African Academy for Science and Arts, the award was jointly made to Prof Steyn, who is probably the best-known South African language historian, and Prof Jan van der Watt van Nijmegen from the Netherlands. The prize money of R500 000, which they will share, will be presented in Stellenbosch on 30 May 2017.

Prof Steyn is a former Kovsie, who was a research professor at the UFS from 1985 to 1997, and at the age of 78 is still a research fellow. “After the announcement of the prize, I learnt that I was nominated by two of my colleagues,” he says.

His most difficult work was probably also his best
Over the past 50 years several of his publications, biographies, and books have seen the light. He believes that nothing one does is perfect. His most difficult work was the biography of NP van Wyk Louw. “It was probably also my best work,” he says. “The book I enjoyed working on most, was the biography of the author MER, or ME Rothmann.”

Prof Steyn has also received awards such as the Stals Prize, the Louis Hiemstra Prize, the NP van Wyk Louw medal, and honorary membership from the South African Academy for Science and Arts.

He says the staff in the Department of Afrikaans and Dutch, German and French are very friendly and helpful to still render him assistance as a research fellow.

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