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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Two Kovsies in Baby Boks group for U20 Championship
2017-05-12

Description: ' 000 Baby Boks Tags: Baby Boks 2017

Scrumhalf Rewan Kruger, left, and prop Kwenzo Blose, both
rugby players from the University of the Free State, will
soon be playing in their first and second Junior World
Tournament respectively.
Photo: SA Rugby

Although he will soon be playing in his first Junior World Cup, Rewan Kruger believes his experience of international rugby will help him succeed. Last year, the scrumhalf was part of the South African schools team playing in the U19 series against Italy, Wales, England, and France.
Kruger and prop Kwenzo Blose, who will be playing in his second World Tournament, are two players from the University of the Free State that were recently included in the final Baby Boks group of 28. The World Rugby U20 Championship will take place in Tbilisi, Georgia from 31 May to 18 June.

A taste of international rugby

The 19-year-old Kruger says it is hard to describe how thrilled he is about his inclusion. “The whole group of players were gathered in a room and the next moment the coach [Chean Roux] played a video on his computer, announcing the team that will be playing abroad.”
The former Grey College, Bloemfontein, pupil has already had a taste of international rugby. “I believe the experience I gained in the international U19 series will help me a lot in the upcoming U20 World Rugby Championship. I already have an idea of the pace of an international game.”

Team can improve on previous year

Blose, KovsieSport’s Junior Sportsman for 2016, says the South African U20 team could do better than the fourth place they got in Manchester, England in 2016. “South Africa is a strong rugby nation and we have set high standards for ourselves. Therefore, we will do our best to win the tournament. We have a great group and I believe we have the potential to win the trophy.”
The former lock from Glenwood High School, Durban, says it has helped his team to play practice matches against senior teams such as the Griquas. “The preparation was tough and I think it will benefit the team.”

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